| Lipid composition and virulence of Mycobacterium tuberculosis H37Rv. | |
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MedLine Citation:
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PMID: 6819845 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The total lipids increased with decrease in total phospholipids in Mycobacterium tuberculosis H37Rv grown at 30 degrees as compared to 37 degrees. Oleic and elaidic acid supplemented to the growth medium resulted in a higher total lipid and phospholipid content, but the content was lower in cells grown in the presence of palmitoleic acid. Cellular content of mannophosphoinositides decreased, whereas that of phosphatidylethanolamine and cardiolipin increased at the lower temperature. A decrease in mannophosphoinositides and an increase in cardiolipin were noted with all fatty acid supplements; however, phosphatidylethanolamine behaved differently. The unsaturated to saturated fatty acids ratio increased at low temperature with oleic and elaidic acid supplements, but it decreased with palmitoleic acid. Cells from media supplemented with palmitoleic acid were found to be most virulent to guinea-pigs. Possible correlation of altered lipid composition and virulence of M. tuberculosis H37Rv has been discussed. |
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Authors:
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G K Khuller; R Taneja; S Kaur; J N Verma |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Australian journal of experimental biology and medical science Volume: 60 (Pt 5) ISSN: 0004-945X ISO Abbreviation: Aust J Exp Biol Med Sci Publication Date: 1982 Oct |
Date Detail:
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Created Date: 1983-04-07 Completed Date: 1983-04-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0416662 Medline TA: Aust J Exp Biol Med Sci Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 541-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Culture Media Fatty Acids / analysis, pharmacology Fatty Acids, Unsaturated / analysis Guinea Pigs Lipids / analysis* Mycobacterium tuberculosis / analysis, growth & development, pathogenicity* Phospholipids / analysis Temperature |
| Chemical | |
Reg. No./Substance:
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0/Culture Media; 0/Fatty Acids; 0/Fatty Acids, Unsaturated; 0/Lipids; 0/Phospholipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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