| Lipid composition of the plasma membrane isolated from hyperplastic nodules of rat liver. | |
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MedLine Citation:
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PMID: 4019434 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hyperplastic nodules and hepatomas were induced in livers of rats fed a diet containing 0.05% N-2-fluorenylacetamide (2-FAA). The lipid contents, and phospholipid and fatty acid compositions were analyzed in plasma membranes (PM's) isolated from these tissues and normal rat liver, and the following trends were observed. The molar ratio of cholesterol to phospholipid-phosphorus (phospholipid-P) increased in the order: hepatoma less than normal liver less than hyperplastic nodules. The molar percentage of plasmalogen to phospholipid-P decreased in the order: hepatoma = hyperplastic nodules greater than normal liver. The percentages of choline phosphoglycerides (sum of phosphatidylcholine and lysophosphatidylcholine) and ethanolamine phosphoglycerides (sum of phosphatidylethanolamine and lysophosphatidylethanolamine) both decreased in the order: hepatoma greater than hyperplastic nodules greater than normal liver. On the other hand, the percentages of sphingomyelin and phosphatidylserine both increased in the order: hepatoma less than hyperplastic nodules less than normal liver. As regards fatty acid composition, the percentages of both 18:1 and 18:2 decreased in the order: hepatoma greater than hyperplastic nodules greater than normal liver. Those of 18:0 and 20:4 increased in the order: hepatoma less than hyperplastic nodules less than normal liver. These results suggested that the lipid bilayer in PM of hyperplastic nodules has characteristics roughly intermediate between those of hepatoma and liver PM's, although the molar ratio of cholesterol to phospholipid-P in hyperplastic nodules PM was not intermediate. |
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Authors:
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K Tamiya-Koizumi; K Koizumi; H Ishihara; K Kojima |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of biochemistry Volume: 97 ISSN: 0021-924X ISO Abbreviation: J. Biochem. Publication Date: 1985 Mar |
Date Detail:
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Created Date: 1985-09-04 Completed Date: 1985-09-04 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0376600 Medline TA: J Biochem Country: JAPAN |
Other Details:
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Languages: eng Pagination: 773-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chemical Phenomena Chemistry Cholesterol / analysis Fatty Acids / analysis Hyperplasia / metabolism Liver / metabolism*, pathology Liver Neoplasms, Experimental / metabolism* Male Membrane Lipids / isolation & purification* Phospholipids / analysis Plasmalogens / analysis Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Membrane Lipids; 0/Phospholipids; 0/Plasmalogens; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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