Document Detail


Lipid composition of hepatic and adipose tissues from normal cats and from cats with idiopathic hepatic lipidosis.
MedLine Citation:
PMID:  9298479     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to characterize the lipid classes in hepatic and adipose tissues from cats with idiopathic hepatic lipidosis (IHL). Concentrations of triglyceride, phospholipid phosphorus, and free and total cholesterol were determined in lipid extracts of liver homogenates from 5 cats with IHL and 5 healthy control cats. Total fatty acid composition of liver and adipose tissue was also compared. Triglyceride accounted for 34% of liver by weight in cats with IHL (338 +/- 38 mg/g wet liver) versus 1% in control cats (9.9 +/- 1.0 mg/g wet liver, P < .001). The mass of cholesterol ester was significantly higher in triglyceride-free (TG-free) liver from cats with IHL (741 +/- 340 micrograms/g TG-free wet liver) compared to healthy cats (31 +/- 11 micrograms/g TG-free wet liver, P < .05). Total fatty acid composition of hepatic tissue in the 2 groups differed; palmitate was higher (19.5 +/- 1.1% of total fatty acids in cats with IHL versus 9.2 +/- 2.7% in controls, P < .05), stearate was lower (8.5 +/- 0.8% versus 16.8 +/- 1.1%, P < .05), oleate was higher (41.2 +/- 1.6% versus 31.1 +/- 1.8%, P < .05), and arachidonate was lower (1.2 +/- 0.2% versus 6.0 +/- 0.9%, P < .05). The total fatty acid composition of adipose tissue also differed between the 2 groups; palmitate was higher (26.2 +/- 1.2% in cats with IHL versus 21.3 +/- 0.6% in controls, P < .05), total monounsaturated fatty acids were higher (48.4 +/- 1.0% versus 45.0 +/- 0.8%, P < .05), linolenate was lower (13.3 +/- 1.6% versus 17.5 +/- 0.9%, P < .05), total (n-6) fatty acids were lower (13.8 +/- 1.38% versus 18.4 +/- 0.83%, P < .05), linolenate was lower (0.2 +/- 0.04% versus 0.7 +/- 0.06%, P < .06), and total (n-3) fatty acids were lower (0.3 +/- 0.02% versus 1.3 +/- 0.32%, P < .05). The fatty acid composition of both liver and adipose tissue was similar for stearate, oleate, linoleate, and linolenate in cats with IHL. These results support the hypothesis that the origin of hepatic triglyceride in cats with IHL is the mobilization of fatty acids from adipose tissue.
Authors:
J A Hall; L A Barstad; W E Connor
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of veterinary internal medicine / American College of Veterinary Internal Medicine     Volume:  11     ISSN:  0891-6640     ISO Abbreviation:  J. Vet. Intern. Med.     Publication Date:    1997 Jul-Aug
Date Detail:
Created Date:  1997-11-06     Completed Date:  1997-11-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8708660     Medline TA:  J Vet Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  238-42     Citation Subset:  IM    
Affiliation:
College of Veterinary Medicine, Oregon State University, Corvallis 97331-4802, USA.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / chemistry*,  metabolism
Animals
Arachidonic Acid / analysis,  metabolism
Cat Diseases / metabolism*
Cats
Cholesterol Esters / analysis,  metabolism
Fatty Acids / analysis,  metabolism
Female
Linoleic Acid / analysis,  metabolism
Lipid Metabolism
Lipidoses / metabolism,  veterinary*
Lipids / analysis*
Liver / chemistry*,  metabolism
Liver Diseases / metabolism,  veterinary*
Male
Oleic Acid / analysis,  metabolism
Palmitates / analysis,  metabolism
Phospholipids / analysis,  metabolism
Stearates / analysis,  metabolism
Triglycerides / analysis,  metabolism
alpha-Linolenic Acid / analysis,  metabolism
Chemical
Reg. No./Substance:
0/Cholesterol Esters; 0/Fatty Acids; 0/Lipids; 0/Palmitates; 0/Phospholipids; 0/Stearates; 0/Triglycerides; 112-80-1/Oleic Acid; 2197-37-7/Linoleic Acid; 463-40-1/alpha-Linolenic Acid; 506-32-1/Arachidonic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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