Document Detail

Lipid changes associated with erythroid differentiation of Friend erythroleukemia cells.
MedLine Citation:
PMID:  3475757     Owner:  NLM     Status:  MEDLINE    
Friend erythroleukemia cells were induced to differentiate by dimethyl sulfoxide (DMSO) and hexamethylene-bis-acetamide (HBMA) in order to investigate whether their lipid characteristics, common to other systems of transformed cells, revert to a normal differentiation pattern. DBA/2 mouse erythrocytes were examined as a model of terminal differentiation in erythroid lineage. Variants of erythroleukemia cells not inducible to erythroid differentiation by DMSO and HMBA were also used in this study, in order to test whether lipid modifications occurring in differentiated erythroleukemia cells were related to the differentiation process or caused by specific effects of the inducers. Friend erythroleukemia cells showed the same lipid characteristics as those found in other transformed cell types. That is, a high level of ether-linked lipids and low percentages of long chain polyunsaturated fatty acids along with an accumulation of monoenoic fatty acids in phospholipids. These lipid characteristics remained unchanged when erythroleukemia cells were induced to differentiation by either DMSO or HMBA. However, other lipid components of erythroleukemia cells, e.g., phosphatidylethanolamine and triglycerides, were affected by erythroid differentiation. There were also changes of some lipid components of erythroleukemia cells, such as cholesteryl esters, which were related to specific effects of the inducers. Both DMSO- and HMBA-resistant variants differed from the inducible erythroleukemia cells, mainly in their ether-linked phospholipid pattern.
A Fallani; A Arcangeli; S Ruggieri
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Toxicologic pathology     Volume:  15     ISSN:  0192-6233     ISO Abbreviation:  Toxicol Pathol     Publication Date:  1987  
Date Detail:
Created Date:  1987-09-22     Completed Date:  1987-09-22     Revised Date:  2009-07-01    
Medline Journal Info:
Nlm Unique ID:  7905907     Medline TA:  Toxicol Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  170-7     Citation Subset:  IM    
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MeSH Terms
Acetamides / pharmacology
Cell Differentiation / drug effects
Cell Line
Cholesterol / analysis
Dimethyl Sulfoxide / pharmacology
Fatty Acids, Nonesterified / analysis
Leukemia, Erythroblastic, Acute / pathology*
Leukemia, Experimental / pathology*
Lipids / analysis*
Phospholipids / analysis
Triglycerides / analysis
Reg. No./Substance:
0/Acetamides; 0/Fatty Acids, Nonesterified; 0/Lipids; 0/Phospholipids; 0/Triglycerides; 3073-59-4/hexamethylene bisacetamide; 57-88-5/Cholesterol; 67-68-5/Dimethyl Sulfoxide

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