Document Detail

Lipid chain length alterations during placental transfer in the guinea pig.
MedLine Citation:
PMID:  4056336     Owner:  NLM     Status:  MEDLINE    
Using an in situ perfusion of the fetal side of the guinea-pig placenta the modification of a non-esterified fatty acid during transfer across the placenta was investigated. Simultaneous constant infusions of [9,10(3)H] palmitic acid and [1-14C] palmitic acid (3 animals) or [9,10(3)H] and [6-14C] palmitic acids (3 animals) or [9,10(3)H] and universal [14C] palmitic acids (3 animals) were given to the mothers and blood samples and perfusion fluid collected over 90 min in each experiment. When expressed as a ratio of perfusion fluid/maternal plasma radioactive counts, no difference between [3H] isotopes results were found for the 3 triplets of experiments. However significant differences were found between the [14C] isotope ratios. More radioactive lipid was found in the perfusion fluid when the label was positioned away from the C1 terminal of the fatty acid chain, i.e. the ratios were [1-14C] less than [6-14C] less than [9,10(3)H] less than universal [14C] palmitic acid. It was concluded that this indicates release of partially oxidised fatty acid products from the fetal side of the placenta, and it was speculated that this partial oxidation takes place in placental peroxisomes.
C R Thomas; J L Evans; C Buttriss; C Lowy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of developmental physiology     Volume:  7     ISSN:  0141-9846     ISO Abbreviation:  J. Dev. Physiol.     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1985-12-13     Completed Date:  1985-12-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7910737     Medline TA:  J Dev Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  305-11     Citation Subset:  IM    
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MeSH Terms
Antipyrine / metabolism
Blood Pressure
Fatty Acids, Unsaturated / metabolism
Guinea Pigs
Lipids / analysis*
Palmitic Acid
Palmitic Acids / metabolism
Placenta / metabolism*
Time Factors
Reg. No./Substance:
0/Fatty Acids, Unsaturated; 0/Lipids; 0/Palmitic Acids; 57-10-3/Palmitic Acid; 60-80-0/Antipyrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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