Document Detail

Lipid and apoprotein modifications in body builders during and after self-administration of anabolic steroids.
MedLine Citation:
PMID:  2105436     Owner:  NLM     Status:  MEDLINE    
To determine the effects of anabolic steroids on serum lipid and apoprotein levels, 14 white male body builders who self-administered steroids for 2 to 3 months (steroid users) were studied; 10 agreed to screening while they were taking the drugs (ON treatment) and also at about 3 months following their suspension (OFF treatment). Controls consisted of 17 body builders who had never taken steroids (nonusers), and a group of 18 healthy sedentary subjects (controls). During the period of steroid administration, there was a slight reduction in total serum cholesterol, with a marked cholesterol decrease in the high-density lipoprotein (HDL) subfractions HDL2 and HDL3, and a significant reduction in the HDL2 cholesterol/HDL3 cholesterol ratio; the percentage of serum cholesterol transported by low-density lipoproteins (LDL) increased significantly. In addition, a marked apoprotein (apo) A-I reduction in the HDL2 and HDL3 subfractions was observed, as well as an apo A-II decrease that was significant only in the HDL3 subfraction, with an A-I/A-II ratio significantly reduced in both subfractions. Serum apo B was only slightly increased, with a very high B/A-I ratio. Apolipoprotein C-II and E levels showed no modifications, while apo C-III reduced significantly. Lipid and apoprotein values returned to almost normal levels in the OFF treatment period. Findings in the group of nonusers were similar to those in sedentary subjects. These results indicate that anabolic steroids profoundly alter the serum lipid-protein profile, and the changes may be caused in part by the significant differences observed in apoprotein levels.
G Baldo-Enzi; F Giada; G Zuliani; L Baroni; E Vitale; G Enzi; P Magnanini; R Fellin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  39     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-02-26     Completed Date:  1990-02-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  203-8     Citation Subset:  IM    
Department of Internal Medicine, University of Padua, Italy.
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MeSH Terms
Anabolic Agents / administration & dosage*
Apolipoprotein A-I
Apolipoprotein A-II
Apolipoprotein C-II
Apolipoprotein C-III
Apolipoproteins / blood*
Apolipoproteins A / blood
Apolipoproteins B / blood
Apolipoproteins C / blood
Apolipoproteins E / blood
Cholesterol / blood*
Lipoproteins / blood*
Lipoproteins, HDL / blood
Lipoproteins, HDL2
Lipoproteins, HDL3
Self Administration
Reg. No./Substance:
0/Anabolic Agents; 0/Apolipoprotein A-I; 0/Apolipoprotein A-II; 0/Apolipoprotein C-II; 0/Apolipoprotein C-III; 0/Apolipoproteins; 0/Apolipoproteins A; 0/Apolipoproteins B; 0/Apolipoproteins C; 0/Apolipoproteins E; 0/Lipoproteins; 0/Lipoproteins, HDL; 0/Lipoproteins, HDL2; 0/Lipoproteins, HDL3; 57-88-5/Cholesterol

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