Document Detail

Lipid apheresis and rheopheresis for treatment of peripheral arterial disease.
MedLine Citation:
PMID:  20129378     Owner:  NLM     Status:  In-Data-Review    
Lipid apheresis is an effective lipid-lowering treatment in drug unresponsive severely hypercholesterolemic patients with coronary artery disease. It results in symptomatic improvement, reduces progression of coronary atherosclerosis, and decreases coronary event rates. These effects are partly caused by aggressive lipid lowering itself and partly by unselective removal of high molecular weight proteins leading to improved hemorheology. This review summarizes current available data on the proposed mechanisms by which lipid apheresis acts anti-atherosclerotic and improves ischemic symptoms. Based on this, it discusses the putative effects of lipid apheresis on restoring patho-physiological processes involved in the development of symptoms of peripheral arterial disease and critical limb ischemia. The available clinical experience with lipid apheresis and rheopheresis in treating patients with peripheral arterial disease is then critically reviewed and put into the context of currently available treatment options.
N Weiss
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Atherosclerosis. Supplements     Volume:  10     ISSN:  1878-5050     ISO Abbreviation:  Atheroscler Suppl     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-02-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100973461     Medline TA:  Atheroscler Suppl     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  62-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2009 Elsevier Ireland Ltd. All rights reserved.
University Center for Vascular Medicine and Department of Internal Medicine III, Section Angiology, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Germany.
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