Document Detail

Lipid alterations correlate with tissue magnesium decrease following impact trauma in rabbit spinal cord.
MedLine Citation:
PMID:  2128684     Owner:  NLM     Status:  MEDLINE    
Secondary neurochemical events contribute to progressive tissue damage and subsequent neurological deficit after traumatic spinal-cord injury (SCI). Among proposed injury factors are alterations of phospholipids and certain cations. To clarify the relationship of membrane lipid changes (phospholipids, cholesterol, and arachidonic acid) to changes in tissue content of water and selected ions (sodium, potassium, and magnesium) after SCI, these variables were examined in spinal-cord segments from anesthetized ventilated rabbits subjected to laminectomy or to moderate (40 g-cm) or severe (150 g-cm) impact trauma at the lumbar (L2) segment. Trauma caused significant increases in tissue sodium, water, and arachidonic acid content, and significant decreases in phospholipids, cholesterol, potassium, and magnesium content. Alterations in magnesium were significantly related to injury severity. In contrast, changes in spinal-cord water content occurred to a similar degree in the two injury groups, as did tissue sodium and potassium content. Decreases in phospholipids were strongly correlated with decreases in tissue magnesium content, whereas changes in sodium and potassium were less well-correlated. Because magnesium ions play a critical role with regard to cellular bioenergetic state, calcium flux, amino acid receptor function, and eicosanoid production, reductions in tissue magnesium after injury may be important in the progression of secondary tissue damage.
M Lemke; S W Yum; A I Faden
Related Documents :
15716024 - Cytochrome p450 expression and catalytic activity in coronary arteries and liver of cat...
1250164 - Selenoamino acids in tissues of rats administered inorganic selenium.
16668834 - A rapid method for isolating glandular trichomes.
20600314 - Assaying multiple biochemical variables from the same tissue sample.
11269694 - Effect of conjugated linoleic acid on fungal delta6-desaturase activity in a transforme...
10509214 - Preconception counseling and women's compliance with folic acid supplementation.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid     Volume:  12     ISSN:  1044-7393     ISO Abbreviation:  Mol. Chem. Neuropathol.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1991-06-07     Completed Date:  1991-06-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8910358     Medline TA:  Mol Chem Neuropathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  147-65     Citation Subset:  IM    
Department of Neurology, University of California, San Francisco.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arachidonic Acid
Arachidonic Acids / metabolism*
Cholesterol / metabolism
Magnesium / metabolism*
Phospholipids / metabolism*
Potassium / metabolism
Reference Values
Spinal Cord / metabolism*
Spinal Cord Injuries / metabolism*,  physiopathology
Grant Support
NS 14543/NS/NINDS NIH HHS; R49/CCR 902269//PHS HHS
Reg. No./Substance:
0/Arachidonic Acids; 0/Cations; 0/Phospholipids; 506-32-1/Arachidonic Acid; 57-88-5/Cholesterol; 7439-95-4/Magnesium; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The role of disodium cromoglycate-metered dose aerosol inhaler in the management of asthma in Thai c...
Next Document:  Calcium-dependent phospholipid catabolism and arachidonic acid mobilization in cerebral minces.