Document Detail


Lipid alterations correlate with tissue magnesium decrease following impact trauma in rabbit spinal cord.
MedLine Citation:
PMID:  2128684     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Secondary neurochemical events contribute to progressive tissue damage and subsequent neurological deficit after traumatic spinal-cord injury (SCI). Among proposed injury factors are alterations of phospholipids and certain cations. To clarify the relationship of membrane lipid changes (phospholipids, cholesterol, and arachidonic acid) to changes in tissue content of water and selected ions (sodium, potassium, and magnesium) after SCI, these variables were examined in spinal-cord segments from anesthetized ventilated rabbits subjected to laminectomy or to moderate (40 g-cm) or severe (150 g-cm) impact trauma at the lumbar (L2) segment. Trauma caused significant increases in tissue sodium, water, and arachidonic acid content, and significant decreases in phospholipids, cholesterol, potassium, and magnesium content. Alterations in magnesium were significantly related to injury severity. In contrast, changes in spinal-cord water content occurred to a similar degree in the two injury groups, as did tissue sodium and potassium content. Decreases in phospholipids were strongly correlated with decreases in tissue magnesium content, whereas changes in sodium and potassium were less well-correlated. Because magnesium ions play a critical role with regard to cellular bioenergetic state, calcium flux, amino acid receptor function, and eicosanoid production, reductions in tissue magnesium after injury may be important in the progression of secondary tissue damage.
Authors:
M Lemke; S W Yum; A I Faden
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid     Volume:  12     ISSN:  1044-7393     ISO Abbreviation:  Mol. Chem. Neuropathol.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1991-06-07     Completed Date:  1991-06-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8910358     Medline TA:  Mol Chem Neuropathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  147-65     Citation Subset:  IM    
Affiliation:
Department of Neurology, University of California, San Francisco.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arachidonic Acid
Arachidonic Acids / metabolism*
Cations
Cholesterol / metabolism
Magnesium / metabolism*
Male
Phospholipids / metabolism*
Potassium / metabolism
Rabbits
Reference Values
Spinal Cord / metabolism*
Spinal Cord Injuries / metabolism*,  physiopathology
Grant Support
ID/Acronym/Agency:
NS 14543/NS/NINDS NIH HHS; R49/CCR 902269//PHS HHS
Chemical
Reg. No./Substance:
0/Arachidonic Acids; 0/Cations; 0/Phospholipids; 506-32-1/Arachidonic Acid; 57-88-5/Cholesterol; 7439-95-4/Magnesium; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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