| Lipid abnormalities predict progression of renal disease in patients with type 1 diabetes. | |
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MedLine Citation:
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PMID: 19816673 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS/HYPOTHESIS: We studied the impact of baseline lipid variables on the progression of renal disease in a large nationwide prospective cohort of patients with type 1 diabetes. METHODS: A total of 2,304 adult patients with type 1 diabetes and available lipid profiles participating in the Finnish Diabetic Nephropathy Study (FinnDiane) were evaluated. Data on progression of renal disease were verified from medical files and patients were followed for 5.4 +/- 2.0 (mean +/- SD) years. RESULTS: High triacylglycerol, apolipoprotein (Apo) B, ApoA-II and HDL(3)-cholesterol concentrations predicted incident microalbuminuria. Progression to macroalbuminuria was predicted by high triacylglycerol and ApoB. When AER was entered into the model, triacylglycerol was no longer an independent predictor, but when patients with normal AER and microalbuminuria at baseline were pooled, triacylglycerol, HbA(1c), male sex and AER were all independent predictors of renal disease. High total cholesterol, LDL-cholesterol, non-HDL-cholesterol and triacylglycerol as well as low HDL-cholesterol, HDL(2)-cholesterol, ApoA-I and ApoA-II concentrations were predictive of progression to end-stage renal disease. However, when estimated GFR was entered into the model, only total cholesterol remained an independent predictor of progression. CONCLUSIONS/INTERPRETATION: Lipid abnormalities, particularly high triacylglycerol concentrations, increase the risk of progression of renal disease. |
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Authors:
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N Tolonen; C Forsblom; L Thorn; J Wad?n; M Roseng?rd-B?rlund; M Saraheimo; M Feodoroff; V-P M?kinen; D Gordin; M-R Taskinen; P-H Groop; |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-10-10 |
Journal Detail:
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Title: Diabetologia Volume: 52 ISSN: 1432-0428 ISO Abbreviation: Diabetologia Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2010-01-21 Completed Date: 2010-04-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0006777 Medline TA: Diabetologia Country: Germany |
Other Details:
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Languages: eng Pagination: 2522-30 Citation Subset: IM |
Affiliation:
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Folkh?lsan Institute of Genetics, Folkh?lsan Research Center, University of Helsinki, Biomedicum Helsinki (C318b), Haartmaninkatu 8, PO Box 63, 00014, Helsinki, Finland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age of Onset Apolipoprotein A-II / blood Apolipoproteins B / blood Blood Pressure Cohort Studies Diabetes Mellitus, Type 1 / blood, complications* Diabetic Neuropathies / blood, epidemiology, physiopathology* Disease Progression Female Finland / epidemiology Follow-Up Studies Humans Lipids / physiology* Male Middle Aged Predictive Value of Tests Prospective Studies Time Factors Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein A-II; 0/Apolipoproteins B; 0/Lipids; 0/Triglycerides |
| Investigator | |
Investigator/Affiliation:
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S Koivula / ; T Uggeldahl / ; T Forslund / ; A Halonen / ; A Koistinen / ; P Koskiaho / ; M Laukkanen / ; J Saltevo / ; M Tiihonen / ; A-C Blomqvist / ; M Forsen / ; H Granlund / ; B Nyroos / ; P Kinnunen / ; A Orvola / ; T Salonen / ; A V?h?nen / ; R Paldanius / ; M Riihel? / ; L Ryysy / ; P Nyl?nden / ; A Sademies / ; S Anderson / ; B Asplund / ; U Byskata / ; T Virkkala / ; A Nikkola / ; E Ritola / ; L Penttinen / ; H-L Siekkinen / ; A Kaprio / ; J K?rkka?inen / ; B Rantaeskola / ; S Klemetti / ; T Nyandoto / ; E Rontu / ; S Satuli-Autere / ; R Toivonen / ; H Virtanen / ; M Laine / ; T Pellonp?? / ; R Puranen / ; A Airas / ; J Laakso / ; K Rautavaara / ; M Erola / ; E Jatkola / ; R L?nnblad / ; A Malm / ; J M?kel? / ; E Rautamo / ; P Hentunen / ; J Lagerstam / ; H Rosvall / ; T Kalliom?ki / ; J Koskelainen / ; R Nikkanen / ; N Savolainen / ; H Sulonen / ; E Valtonen / ; E Toivanen / ; A Parta / ; I Pirttiniem / ; S Aranko / ; S Ervasti / ; R Kauppinen-M?kelin / ; A Kuusisto / ; T Lepp?l? / ; K Nikkil? / ; L Pekkonen / ; S Jokelainen / ; P Kemppainen / ; A-M Mankinen / ; M Sankari / ; A Aimolahti / ; E Huovinen / ; V Ilkka / ; M Lehtim?ki / ; E Koskinen / ; T Siitonen / ; E Huttunen / ; R Ik?heimo / ; P Karhap?? / ; P Kek?l?inen / ; M Laakso / ; T Lakka / ; E Lampainen / ; L Mykk?nen / ; L Niskanen / ; U Tuovinen / ; I Vauhkonen / ; E Voutilainen / ; E Kilkki / ; L Riihel? / ; T Meril?inen / ; P Poukka / ; R Savolainen / ; N Uhlenius / ; A M?kel? / ; M Tanner / ; L Hyv?rinen / ; S Severinkangas / ; T Tulokas / ; P Linkola / ; I Pulli / ; T Granlund / ; M Saari / ; T Salonen / ; I-M Jousmaa / ; J Rinne / ; H Lanki / ; S Moilanen / ; M Tilly-Kiesi / ; A Gynther / ; R Manninen / ; P Nironen / ; M Salminen / ; T V?nttinen / ; U-M Henttula / ; A Rissanen / ; P Kek?l?inen / ; M Voutilainen / ; E Jokelainen / ; P-L Jylkk? / ; E Kaarlela / ; J Vuolaspuro / ; L Hiltunen / ; R H?kkinen / ; S Kein?nen-Kiukaanniemi / ; H Haapam?ki / ; A Helanter? / ; H Miettinen / ; P Sopanen / ; L Welling / ; K M?kinen / ; P Sopanen / ; V Javtsenko / ; M Tamminen / ; M-L Holmb?ck / ; B Isomaa / ; P Ahonen / ; P Merensalo / ; K S?vel? / ; M Kallio / ; B Rask / ; A Holma / ; M Honkala / ; A Tuomivaara / ; R Vainionp?? / ; K Laine / ; K Saarinen / ; T Salminen / ; E Immonen / ; L Juurinen / ; A Alanko / ; J Lapinleimu / ; P Rautio / ; M Virtanen / ; M Asola / ; M Juhola / ; P Kunelius / ; M-L Lahdenm?ki / ; P P??kk?nen / ; M Rautavirta / ; T Pulli / ; P Sallinen / ; E Tolvanen / ; H Valtonen / ; A Vartia / ; E Korpi / ; T Latvala / ; E Leijala / ; T Hotti / ; R H?rk?nen / ; U Nyholm / ; J Toivanen / ; I Ala-Houhala / ; T Kuningas / ; P Lampinen / ; M M??tt? / ; H Oksala / ; T Oksanen / ; K Salonen / ; H Tauriainen / ; S Tulokas / ; T Kivel? / ; L Petlin / ; L Savolainen / ; I H?m?l?inen / ; H Virtamo / ; M V?h?talo / ; K Breitholz / ; R Eskola / ; K Mets?rinne / ; U Pietil? / ; P Saarinen / ; R Tuominen / ; S Ayr?p?? / ; I Isom?ki / ; R Kroneld / ; M Tapiolinna-M?kel? / ; S Bergkulla / ; U Hautam?ki / ; V-A Myllyniemi / ; I Rusk / |
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