Document Detail


Lipid abnormalities in foam cell reticulosis of mice, an analogue of human sphingomyelin lipidosis.
MedLine Citation:
PMID:  4306614     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The lipid changes in the inheritable foam cell reticulosis of mice discovered by Lyons, Hulse, and Rowe have been reexamined. The major abnormality in thymuses from homozygous-abnormal animals has been identified as an increase in the concentration (per milligram of protein) of sphingomyelin and cholesterol. This increase is associated with normal sphingomyelin-cleaving activity. The lipid compositions of the liver and spleen in the homozygous-abnormal animal and of the thymus in the heterozygous-abnormal mouse are normal. The disorder appears to be chemically analogous to those forms of human sphingomyelin lipidosis (Niemann-Pick disease) that are not accompanied by a decrease in tissue sphingomyelinase.
Authors:
D S Fredrickson; H R Sloan; C T Hansen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of lipid research     Volume:  10     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  1969 May 
Date Detail:
Created Date:  1969-08-01     Completed Date:  1969-08-01     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  288-93     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Carbon Isotopes
Cholesterol / metabolism
Chromatography, Thin Layer
Heterozygote
Homozygote
Humans
Lipoproteins / blood
Liver / enzymology,  metabolism*
Lymphatic Diseases*
Lysophosphatidylcholines / metabolism
Mice
Niemann-Pick Diseases
Phenotype
Phosphatidylcholines / metabolism
Phosphatidylethanolamines / metabolism
Phosphatidylinositols / metabolism
Phospholipases / metabolism
Phospholipids / metabolism*
Sphingomyelins / metabolism*
Spleen / enzymology,  metabolism*
Thymus Gland / enzymology,  metabolism*
Chemical
Reg. No./Substance:
0/Carbon Isotopes; 0/Lipoproteins; 0/Lysophosphatidylcholines; 0/Phosphatidylcholines; 0/Phosphatidylethanolamines; 0/Phosphatidylinositols; 0/Phospholipids; 0/Sphingomyelins; 57-88-5/Cholesterol; EC 3.1.-/Phospholipases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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