| Lipid Mediators in Cerebral Spinal Fluid of Traumatic Brain Injured Patients. | |
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MedLine Citation:
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PMID: 21427623 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND:: Enzymatic and nonenzymatic oxidation of polyunsaturated fatty acids leads to the formation of biologically active products known as lipid mediators. In the brain, lipid mediators play an important role in supporting homeostasis and normal function. Thus, levels of these metabolites in normal and pathologic conditions in the brain are particularly relevant in understanding the transition to disease. METHODS:: In this study, liquid chromatography tandem mass spectrometry was used to analyze lipid mediators in cerebrospinal fluid (CSF) of controls and traumatic brain injured (TBI) patients. RESULTS:: Our results showed that the levels of arachidonic acid (AA), docosahexaenoic acid (DHA), 5- and 12- eicosatetraenoic acid (HETE) were significantly increased in the CSF of TBI patients. The magnitude of increase was 10-fold for AA, DHA, and 5-HETE and 17-fold for 12-HETE. Prostaglandins and leukotrienes were not detected in CSF of either control or brain injured patients. Furthermore, this study found that isoprostanes and thromboxanes are present in CSF of brain injured patients. CONCLUSIONS:: This study clearly shows that certain lipid mediators accumulate in the CSF of TBI patient. This study also suggests the potential use of DHA, AA, 5- and 12-HETE as biochemical markers of brain injury and to monitor the impact of interventions. |
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Authors:
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Santiago E Farias; Kim A Heidenreich; Max V Wohlauer; Robert C Murphy; Ernest E Moore |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-21 |
Journal Detail:
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Title: The Journal of trauma Volume: - ISSN: 1529-8809 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376373 Medline TA: J Trauma Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the Department of Pharmacology (S.E.F., K.A.H., R.C.M.), University of Colorado at Denver, Anschutz Medical Campus, Aurora, CO; and Department of Surgery (M.V.W., E.E.M.), Denver Health Medical Center, UCD, Denver, CO. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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