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Lipid-Lowering and Antioxidant Functions of Bottle Gourd (Lagenaria siceraria) Extract in Human Dyslipidemia.
MedLine Citation:
PMID:  24647091     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The study validated the antidyslipidemic, antioxidant, and antihyperglycemic effects of Lagenaria siceraria fruit extract in human subjects with dyslipidemia along with subjects of normal health. A total of 200 mL of freshly prepared Lagenaria siceraria fruit extract was administered daily on empty stomach for 90 days. Significant reductions (P < .01) were found in triglycerides and total cholesterol levels in blood. Cardiac risk ratio, atherogenic coefficient, and atherogenicity index of plasma were also improved. Appreciable reductions in body mass index (P < .01) and blood pressure (systolic P < .01, diastolic P < .05) along with a significant reduction (P < .05) in fasting blood glucose levels were also observed in these subjects. Lagenaria siceraria fruit extract exhibited significant antioxidant activity in dyslipidemic subjects as evident from elevations in SOD (P < .05) and GSH levels (P < .01) with marked improvement in catalase (P < .01) and TBARS levels (P < .05). Phytochemical screening confirmed the presence of saponins, glycosides, flavonoids, terpenoids, and phenolic compounds. Lagenaria siceraria fruit extract serves as dietary adjunct in treatment of human dyslipidemia and cardiovascular disease.
Authors:
Charu Katare; Sonali Saxena; Supriya Agrawal; Anish Zacharia Joseph; Senthil Kumar Subramani; Dhananjay Yadav; Nita Singh; Prakash Singh Bisen; G B K S Prasad
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-2-20
Journal Detail:
Title:  Journal of evidence-based complementary & alternative medicine     Volume:  -     ISSN:  2156-5899     ISO Abbreviation:  J Evid Based Complementary Altern Med     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-3-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101556804     Medline TA:  J Evid Based Complementary Altern Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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