| Lipid emulsion reverses bupivacaine-induced asystole in isolated rat hearts: concentration-response and time-response relationships. | |
| | |
MedLine Citation:
|
PMID: 21068661 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The concentration-response and time-response relationships of lipid emulsions used to reverse bupivacaine-induced asystole are poorly defined. METHODS: Concentration response across a range of lipid concentrations (0-16%) to reverse bupivacaine-induced asystole were observed using isolated rat heart Langendorff preparation. Cardiac function parameters were recorded during infusion. Concentrations of bupivacaine in myocardial tissue were measured by liquid chromatography and tandem mass spectrometry at the end of the experiment. RESULTS: Although all lipid-treated hearts recovered (cardiac recovery was defined as a rate-pressure product more than 10% baseline), no nonlipid-treated hearts (control group) did so. The ratio of the maximum rate pressure product during recovery to baseline value demonstrated a concentration-dependent relationship among lipid groups, with 0.25, 0.5, 1, 2, 4, 8, and 16%. Mean ± SD values for each corresponding group were 22 ± 4, 24 ± 5, 29 ± 6, 52 ± 11, 73 ± 18, 119 ± 22, and 112 ± 10%, respectively (n = 6, P < 0.01). Rate-pressure product in lipid groups with 4-16% concentrations was lower at 15-40 min than at 1 min, showing a decreasing tendency during recovery phase (P < 0.01). The concentration of myocardial bupivacaine in all lipid-treated groups was significantly lower than in the control group (P < 0.01). It was also lower in lipid groups with 2-16% concentrations than in those with concentrations at 0.25-1% (P < 0.05), with the 16% group lower than groups with 2-8% concentrations (P < 0.001). CONCLUSION: Lipid application in bupivacaine-induced asystole displays a concentration-dependent and time-response relationship in isolated rat hearts. |
| | |
Authors:
|
Ying Chen; Yun Xia; Le Liu; Tong Shi; Kejian Shi; Quanguang Wang; Limei Chen; Thomas J Papadimos; Xuzhong Xu |
Publication Detail:
|
Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Anesthesiology Volume: 113 ISSN: 1528-1175 ISO Abbreviation: Anesthesiology Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-24 Completed Date: 2010-12-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: United States |
Other Details:
|
Languages: eng Pagination: 1320-5 Citation Subset: AIM; IM |
Affiliation:
|
Department of Anesthesiology, First Affiliated Hospital, Wenzhou Medical College, Zhejiang, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Algorithms Anesthetics, Local / antagonists & inhibitors*, pharmacokinetics, toxicity Animals Blood Pressure / drug effects Bupivacaine / antagonists & inhibitors*, pharmacokinetics, toxicity Dose-Response Relationship, Drug Fat Emulsions, Intravenous / pharmacology* Heart / drug effects* Heart Arrest / chemically induced*, drug therapy* Heart Rate / drug effects Male Myocardium / metabolism Rats Rats, Sprague-Dawley Ventricular Function, Left / drug effects |
| Chemical | |
Reg. No./Substance:
|
0/Anesthetics, Local; 0/Fat Emulsions, Intravenous; 2180-92-9/Bupivacaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intraoperative recruitment maneuver reverses detrimental pneumoperitoneum-induced respiratory effect...
Next Document: Inhalation anesthesia increases V/Q regional heterogeneity during spontaneous breathing in healthy s...