Document Detail


Lipid and C-reactive protein levels as risk factors for hearing loss in older adults.
MedLine Citation:
PMID:  23322627     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine the role of cardiovascular disease (CVD) markers, lipids and C-reactive protein, in age-related hearing loss over time.
STUDY DESIGN: Prospective cohort study.
SETTING: Research laboratories at an academic medical center.
SUBJECTS AND METHODS: In total, 837 older adults (mean age 67.5 years) were included. Primary dependent variables were pure-tone thresholds (pure-tone average [PTA]), including "narrow" PTA (0.5, 1, 2, 4 kHz), "broad" PTA (0.5, 1, 2, 3, 4, 6, 8 kHz), low-frequency PTA (0.25, 0.5, 1 kHz), and high-frequency PTA (2, 3, 4, 6, 8 kHz). Repeated-measures mixed regression modeling was used to assess the relationship between C-reactive protein (CRP) and lipid levels with PTAs over time.
RESULTS: In a cross-sectional sample of 837 subjects, modest associations were found between triglycerides and all PTAs. Weak associations were observed between the ratio of total cholesterol and high-density lipoprotein and narrow PTA, broad PTA, and high-frequency PTA. However, when assessing changes in hearing and lipids over time in a longitudinal analysis, no significant associations between hearing and lipids remained. PTAs and CRP were not statistically associated when controlling for age and sex.
CONCLUSION: Associations between hearing and blood lipids have been the focus of scientific inquiry for more than 50 years. The current results suggest that the association is either spurious or too small to be of consequence in the assessment and treatment of hearing loss in older adults. Inquiry into other potential risk factors for age-related hearing loss and associations with CVD may prove more fruitful.
Authors:
Annie N Simpson; Lois J Matthews; Judy R Dubno
Related Documents :
15750697 - Regional variations in microstructural properties of vertebral trabeculae with aging.
15567617 - Triangle identified at the proximal end of femur: a new sex determinant.
16118297 - Muscular development and physical activity as major determinants of femoral bone mass a...
20412367 - Analysis of age-at-death estimation using data from a new, modern autopsy sample--part ...
19478787 - Relationship between basal metabolic rate, gender, age, and body composition in 8,780 w...
1787527 - Serum insulin-like growth factor 1 concentrations in the developing rhesus monkey.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-15
Journal Detail:
Title:  Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery     Volume:  148     ISSN:  1097-6817     ISO Abbreviation:  Otolaryngol Head Neck Surg     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-28     Completed Date:  2013-06-17     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  8508176     Medline TA:  Otolaryngol Head Neck Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  664-70     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Age Factors
Aged
Biological Markers / blood
C-Reactive Protein / analysis*
Female
Hearing Loss / blood*
Humans
Lipids / blood*
Male
Middle Aged
Prospective Studies
Risk Factors
Grant Support
ID/Acronym/Agency:
C06 RR14516/RR/NCRR NIH HHS; P50 DC000422/DC/NIDCD NIH HHS; P50 DC00422/DC/NIDCD NIH HHS; UL1 RR029882/RR/NCRR NIH HHS; UL1 RR029882/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Lipids; 9007-41-4/C-Reactive Protein
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Endotracheal Nitinol Stents: Lessons from the Learning Curve.
Next Document:  Osseointegrated hearing implant surgery: outcomes using a minimal soft tissue removal technique.