Document Detail

MedLine Citation:
PMID:  12400054     Owner:  NLM     Status:  MEDLINE    
In 1949, Linus Pauling and his collaborators published a study in the journal Science entitled "Sickle Cell Anemia, a Molecular Disease." In this now classic study, they showed that hemoglobin from patients suffering from sickle cell anemia has a different electrical charge than hemoglobin from healthy individuals. This result demonstrated for the first time that an abnormal protein could be causally linked to a disease, and that genes determined the structure of proteins. This report made headline news and had a powerful impact on both the biomedical community and the general public. Fifty years later, this study is discussed in almost every medical and biological textbook and has became a favorite example in editorials to illustrate the progress of biomedical research. This article explores the history of Pauling's sickle cell anemia and its subsequent integration in different collective memories, up to the present day. It also discusses the function of the collective memories of Pauling's discovery for contemporary biomedical research.
Bruno J Strasser
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Publication Detail:
Type:  Biography; Historical Article; Journal Article; Portraits; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of medical genetics     Volume:  115     ISSN:  0148-7299     ISO Abbreviation:  Am. J. Med. Genet.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-10-25     Completed Date:  2003-03-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7708900     Medline TA:  Am J Med Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  83-93     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Wiley-Liss, Inc.
Institute for the History of Medicine and Health, University of Geneva, Switzerland.
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MeSH Terms
Anemia, Sickle Cell / etiology,  history*
Genetics, Medical / history*
History, 20th Century
Legislation, Medical / history
Molecular Biology / history*,  instrumentation
Research Support as Topic
United States
Personal Name Subject
Personal Name Subject:
Linus Pauling

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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