Document Detail


α-Linolenic acid, linoleic acid and heart failure in women.
MedLine Citation:
PMID:  22172525     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
α-Linolenic acid (18 : 3n-3) intake and linoleic acid (18 : 2n-6) intake have been associated with lower rates of CHD, though results have not been consistent. The relationship of these fatty acids with incident heart failure (HF) is not well established. We examined the hypothesis that women with higher intakes of 18 : 3n-3 and 18 : 2n-6 would have lower rates of HF hospitalisation and mortality. We measured 18 : 3n-3 and 18 : 2n-6 intake in 36 234 Swedish Mammography Cohort participants aged 48-83 years using FFQ and followed participants through Swedish inpatient and cause-of-death registers from 1 January 1998 until 31 December 2006. Cox models were used to calculate incidence rate ratios (RR) and 95 % CI. Because of multicollinearity, 18 : 3n-3 and 18 : 2n-6 were examined separately. Over 9 years, 596 women were hospitalised and fifty-five died due to HF. In models accounting for age and other covariates, the RR for HF comparing the top quintile of 18 : 3n-3 (median 1·50 g/d) with the bottom quintile (median 0·88 g/d) was 0·91 (95 % CI 0·71, 1·17, Ptrend = 0·41). The RR comparing the top quintile of 18 : 2n-6 (median 7·8 g/d) with the bottom quintile (median 4·6 g/d) was 1·14 (95 % CI 0·88, 1·46, Ptrend = 0·36). We did not find evidence for the interaction of 18 : 3n-3 and 18 : 2n-6 with each other or with long-chain n-3 fatty acids. In conclusion, these data do not support our hypothesis that 18 : 3n-3 and 18 : 2n-6 are associated with HF. However, these results may not be generalisable to populations with higher intakes of 18 : 3n-3.
Authors:
Emily B Levitan; Alicja Wolk; Niclas Håkansson; Murray A Mittleman
Related Documents :
6246475 - Metabolic adaptation in developing lung.
9142695 - Peroxisomes in adrenal steroidogenesis.
8102045 - Effects of proglycosyn (ly177507) on fatty acid metabolism in rat hepatocytes.
16658215 - Effects of proline and carbohydrates on the metabolism of exogenous proline by excised ...
10956525 - Stereoselective approach to hydroxyindolizidines: protection/deprotection of the nitron...
12895045 - Total synthesis of (+/-)-kainic acid with an aza-[2,3]-wittig sigmatropic rearrangement...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-15
Journal Detail:
Title:  The British journal of nutrition     Volume:  -     ISSN:  1475-2662     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-7     Citation Subset:  -    
Affiliation:
Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, RPHB 230K, 1530 3rd Avenue S, Birmingham, AL 35294-0022, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Mechanisms underlining gender differences in Phenylephrine contraction of normoglycaemic and short-t...
Next Document:  Ubiquinone (coenzyme Q10) prevents renal mitochondrial dysfunction in an experimental model of type ...