Document Detail

Linolenic acid deficiency: changes in fatty acid patterns in female and male rats raised on a linolenic acid-deficient diet for two generations.
MedLine Citation:
PMID:  628317     Owner:  NLM     Status:  MEDLINE    
Rats were fed for two generations a purified, linolenic acid-deficient diet in which the only source of lipid was purified methyl linoleate. This diet contained about 38 mg linolenic acid/kg diet. Control rats were given the same diet supplemented with methyl linolenate (2,500 mg/kg diet). Male and female rats ranged in age from weaning pups to adults. Lipids were extracted from liver, brain, kidney, spleen, heart, muscle, gastrointestinal tract, lung, ovary, testis, adrenal, plasma, erythrocytes, retina, and adipose tissue. Fatty acids of major phospholipid classes (choline phosphoglycerides, ethanolamine phosphoglycerides, and mixed serine phosphoglycerides plus inositol phosphoglycerides) or of total lipid extracts were measured by gas liquid chromatography. Growth rates and organ weights were similar in control and linolenic acid-deficient rats. The major effect of the deficiency was to lower the proportions of n-3 fatty acids, especially 22:6 n-3, in all the organs analyzed. Docosahexaenoic acid (22:6 n-3) was mainly replaced by 22:5 n-6 in deficient rats. The greatest changes in composition were found in brain, heart, muscle, retina, and liver.
J Tinoco; R Babcock; I Hincenbergs; B Medwadowski; P Miljanich
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Lipids     Volume:  13     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  1978 Jan 
Date Detail:
Created Date:  1978-04-26     Completed Date:  1978-04-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  6-17     Citation Subset:  IM    
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MeSH Terms
Age Factors
Body Weight
Deficiency Diseases / metabolism*
Linoleic Acids / deficiency*,  metabolism
Membrane Lipids / biosynthesis,  metabolism
Organ Size
Sex Factors
Reg. No./Substance:
0/Linoleic Acids; 0/Membrane Lipids

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