Document Detail


Linoleic acid increases chorda tympani nerve responses to and behavioral preferences for monosodium glutamate by male and female rats.
MedLine Citation:
PMID:  18635450     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous studies suggest that the chorda tympani nerve (CT) is important in transmitting fat taste information to the central nervous system. However, the contribution of the CT in this process may depend upon the presence of other taste stimuli and/or differ in males and females. Accordingly, the present study investigated the role of the CT in free fatty acid taste processing by examining electrophysiological activity of the CT in response to the free fatty acid linoleic acid (LA), as well as by measuring behavioral responses to LA-taste mixtures. We recorded whole nerve responses from the CT in response to lingual application of LA with or without monosodium glutamate (MSG) in anesthetized male and female rats. In addition, we examined preferences for MSG + LA taste mixtures in behavioral tests. Although lingual application of LA alone did not produce CT whole nerve responses, coapplication of LA and MSG elicited greater CT responses than did MSG alone. These findings were paralleled by greater preferences for MSG + LA taste mixtures than for MSG alone. In both cases, the effect was particularly pronounced in male rats. Thus LA enhances CT activity and behavioral responses to LA + MSG taste mixtures, although there are sex differences in the effects. These results suggest that CT input is important in mediating behavioral responses to fat taste, but the effects depend upon other taste stimuli and differ in males and females.
Authors:
Jennifer M Stratford; Kathleen S Curtis; Robert J Contreras
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2008-07-16
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  295     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-08     Completed Date:  2008-10-17     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R764-72     Citation Subset:  IM    
Affiliation:
Dept. of Psychology and Program in Neuroscience, The Florida State Univ., Tallahassee, FL 32306-1270, USA.
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MeSH Terms
Descriptor/Qualifier:
Anesthesia
Animals
Chorda Tympani Nerve / drug effects*,  physiology
Dietary Fats / pharmacology
Electrophysiology
Feeding Behavior / drug effects,  physiology
Female
Food Preferences / drug effects*,  physiology
Linoleic Acid / pharmacology*
Male
Rats
Rats, Sprague-Dawley
Sex Characteristics*
Sodium Glutamate / pharmacology*
Taste / drug effects*,  physiology
Tongue / innervation,  physiology
Grant Support
ID/Acronym/Agency:
DC-008934-02/DC/NIDCD NIH HHS; DC-04785/DC/NIDCD NIH HHS; DC-06360/DC/NIDCD NIH HHS; T-32 DC-00044/DC/NIDCD NIH HHS
Chemical
Reg. No./Substance:
0/Dietary Fats; 142-47-2/Sodium Glutamate; 2197-37-7/Linoleic Acid
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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