| Linoleic acid and coronary heart disease. | |
| | |
MedLine Citation:
|
PMID: 18951772 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The extent to which higher intakes of linoleic acid (LA) affect risk for coronary heart disease (CHD) is examined by reviewing a wide variety of study types, mostly in humans. In experimental studies, LA has been shown to lower serum levels of low-density lipoprotein cholesterol (LDL-C), especially when substituted for saturated fatty acids. Such an effect would be expected to reduce risk for CHD. In observational studies in which the dietary intake or serum content of LA were either cross-sectionally or prospectively related risk for CHD, higher LA intakes or serum levels have usually been associated with reduced risk. The pooled results from 5 randomized trials where LA was substituted for saturated fatty acids revealed a significant decrease in risk for CHD events with an LA intake 2-3 times current levels. Thus, current recommendations to consume 5-10% of energy from LA are evidence-based, and should not be reduced. |
| | |
Authors:
|
William S Harris |
Publication Detail:
|
Type: Journal Article; Review Date: 2008-10-31 |
Journal Detail:
|
Title: Prostaglandins, leukotrienes, and essential fatty acids Volume: 79 ISSN: 0952-3278 ISO Abbreviation: Prostaglandins Leukot. Essent. Fatty Acids Publication Date: 2008 Sep-Nov |
Date Detail:
|
Created Date: 2008-12-01 Completed Date: 2009-03-05 Revised Date: 2009-04-16 |
Medline Journal Info:
|
Nlm Unique ID: 8802730 Medline TA: Prostaglandins Leukot Essent Fatty Acids Country: Scotland |
Other Details:
|
Languages: eng Pagination: 169-71 Citation Subset: IM |
Affiliation:
|
Sanford Research/USD, 1100 East 21st Street, Suite 700, Sioux Falls, SD 57105, USA. harrisw@sanfordhealth.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cholesterol, LDL
/
blood Coronary Disease / epidemiology, metabolism* Dietary Fats Evidence-Based Medicine Humans Linoleic Acid / administration & dosage*, metabolism* Randomized Controlled Trials as Topic Risk Factors |
| Chemical | |
Reg. No./Substance:
|
0/Cholesterol, LDL; 0/Dietary Fats; 2197-37-7/Linoleic Acid |
| Comments/Corrections | |
Comment In:
|
Prostaglandins Leukot Essent Fatty Acids. 2009 Jan;80(1):77; author reply 77-8
[PMID:
19147338
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: WITHDRAWN: Variations of maximum mouth-opening capacity and condylar path length during growth perio...
Next Document: Anther smuts of Caryophyllaceae: molecular analyses reveal further new species.