Document Detail

Linoleic acid and coronary heart disease.
MedLine Citation:
PMID:  18951772     Owner:  NLM     Status:  MEDLINE    
The extent to which higher intakes of linoleic acid (LA) affect risk for coronary heart disease (CHD) is examined by reviewing a wide variety of study types, mostly in humans. In experimental studies, LA has been shown to lower serum levels of low-density lipoprotein cholesterol (LDL-C), especially when substituted for saturated fatty acids. Such an effect would be expected to reduce risk for CHD. In observational studies in which the dietary intake or serum content of LA were either cross-sectionally or prospectively related risk for CHD, higher LA intakes or serum levels have usually been associated with reduced risk. The pooled results from 5 randomized trials where LA was substituted for saturated fatty acids revealed a significant decrease in risk for CHD events with an LA intake 2-3 times current levels. Thus, current recommendations to consume 5-10% of energy from LA are evidence-based, and should not be reduced.
William S Harris
Publication Detail:
Type:  Journal Article; Review     Date:  2008-10-31
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  79     ISSN:  0952-3278     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:    2008 Sep-Nov
Date Detail:
Created Date:  2008-12-01     Completed Date:  2009-03-05     Revised Date:  2009-04-16    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  169-71     Citation Subset:  IM    
Sanford Research/USD, 1100 East 21st Street, Suite 700, Sioux Falls, SD 57105, USA.
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MeSH Terms
Cholesterol, LDL / blood
Coronary Disease / epidemiology,  metabolism*
Dietary Fats
Evidence-Based Medicine
Linoleic Acid / administration & dosage*,  metabolism*
Randomized Controlled Trials as Topic
Risk Factors
Reg. No./Substance:
0/Cholesterol, LDL; 0/Dietary Fats; 2197-37-7/Linoleic Acid
Comment In:
Prostaglandins Leukot Essent Fatty Acids. 2009 Jan;80(1):77; author reply 77-8   [PMID:  19147338 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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