Document Detail

Linoleic acid absorption in children with cystic fibrosis.
MedLine Citation:
PMID:  7186027     Owner:  NLM     Status:  MEDLINE    
When safflower oil (triglyceride) was consumed without pancreatic enzymes by children with cystic fibrosis (CF), there was no rise in mean plasma linoleic acid levels over the next 4 h. When linoleic acid monoglyceride (LAM) was consumed, the increase in plasma linoleic acid levels was significantly greater than for safflower oil at 2 (p less than 0.02), 3 (p less than 0.01), and 4 h (p less than 0.01). When free fatty acid (hydrolyzed safflower oil) was ingested, there was almost no increase in plasma linoleic acid levels in CF or control children. The absorption of linoleic acid from triglyceride, but not from LAM, was greater when the CF children also took pancreatic enzymes. Three children with CF had greater increases in plasma linoleic acid levels following ingestion of safflower oil when they took antacid and cimetidine with their pancreatic capsules, compared to when they only took the pancreatic capsules.
H P Chase; N N Welch; M E Rabaglia; J Dupont
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  1     ISSN:  0277-2116     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  1982  
Date Detail:
Created Date:  1983-10-08     Completed Date:  1983-10-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  49-54     Citation Subset:  IM    
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MeSH Terms
Antacids / metabolism
Cimetidine / metabolism
Cystic Fibrosis / metabolism*
Dose-Response Relationship, Drug
Enzymes / metabolism
Linoleic Acids / blood,  metabolism*
Monoacylglycerol Lipases / metabolism
Safflower Oil / metabolism
Time Factors
Grant Support
Reg. No./Substance:
0/Antacids; 0/Enzymes; 0/Linoleic Acids; 51481-61-9/Cimetidine; 8001-23-8/Safflower Oil; EC Lipases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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