| Linoleate enrichment of diet and prostaglandin metabolism in rats. | |
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MedLine Citation:
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PMID: 1142018 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Evidence that biosynthesis of prostaglandins (PG) in tissues of animals deficient in essential fatty acids is dependent on the availability of their precursors has been demonstrated. The purpose of this study was to determine the following: (1) effects of dietary linoleate enrichment on PG biosynthesis in rats; (2) effects of exogenous PGE2 and dietary linoleate on plasma free fatty acids and serum cholesterol in fed and fasted rats. Rats were fed three different concentrations of dietary linoleate as beef tallow, hydrogenated vegetable fat, or corn oil. The concentrations of PGE1 and PGF2a measured by radioimmunoassay were higher in rats fed the fed the beef tallow diet independent of energy status. A decrease in the concentration of PG between fasted and fed rats receiving hydrogenated vegetable fat is discussed in respect to the possible influence of trans isomers of unsaturated fatty acids on the biosynthesis of PG. There were significant effects of fasting on serum cholesterol concentration regardless of diet and significant interactions among effects of PGE2, fasting, and diet, suggesting regulatory effects of PGE2 on serum cholesterol concentration. The increase in plasma free fatty acids associated with fasting was prevented by PGE2 for all diets, but had the most marked effect on rats fed hydrogenated vegetable fat. |
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Authors:
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D H Hwang; M M Mathias; J Dupont; D L Meyer |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of nutrition Volume: 105 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 1975 Aug |
Date Detail:
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Created Date: 1975-10-10 Completed Date: 1975-10-10 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 995-1002 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animal Nutritional Physiological Phenomena Animals Cholesterol / blood Dietary Fats / administration & dosage Energy Metabolism Fatty Acids, Nonesterified / blood Linoleic Acids / administration & dosage, pharmacology* Male Oils / administration & dosage Prostaglandins / biosynthesis, metabolism* Prostaglandins E / blood, pharmacology Prostaglandins F / blood Rats Stereoisomerism Structure-Activity Relationship Zea mays |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Fatty Acids, Nonesterified; 0/Linoleic Acids; 0/Oils; 0/Prostaglandins; 0/Prostaglandins E; 0/Prostaglandins F; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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