Document Detail

Links between hypertension and myocardial infarction.
MedLine Citation:
PMID:  8677859     Owner:  NLM     Status:  MEDLINE    
The mechanisms through which hypertension contributes to the occurrence of myocardial infarction should be discussed from two points of view: (1) common risk factors for the two diseases, such as genetic risk, insulin resistance, sympathetic hyperactivity, and vasoactive substances such as angiotensin K, and (2) linking factors that are induced by hypertension and contribute to the development of atherosclerosis and myocardial infarction, such as atherosclerosis and left ventricular hypertrophy. Mechanical stress on blood vessels because of high blood pressure is an especially important factor in endothelial dysfunction, the progression of atherosclerosis, and plaque rupture. This article concentrates on these factors from the perspective of their relationship with the renin-angiotensin system, because recent multicenter trials have demonstrated that angiotensin-converting enzyme inhibitors are effective for preventing recurrence of myocardial infarction.
H Rakugi; H Yu; A Kamitani; Y Nakamura; M Ohishi; K Kamide; Y Nakata; S Takami; J Higaki; T Ogihara
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American heart journal     Volume:  132     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-08-12     Completed Date:  1996-08-12     Revised Date:  2006-02-27    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  213-21     Citation Subset:  AIM; IM    
Department of Geriatric Medicine, Osaka University Medical School, Japan.
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MeSH Terms
Arteriosclerosis / complications,  metabolism
Cardiomegaly / complications
Hypertension / complications*,  genetics,  physiopathology
Insulin Resistance
Myocardial Infarction / etiology*,  genetics,  physiopathology
Risk Factors
Sympathetic Nervous System / physiopathology

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