Document Detail

Linking specification to differentiation: from proneural genes to the regulation of ciliogenesis.
MedLine Citation:
PMID:  21558799     Owner:  NLM     Status:  Publisher    
Much of developmental biology is concerned with the processes by which cells become committed to particular fates in a regulated fashion, whereas cell biology addresses, among other things, the variety of differentiated forms and functions that cells can acquire. One open question is how the regulators of the former process lead to attainment of the latter. 'High-level' regulators of cell fate specification include the proneural factors, which drive cells to commit as precursors in the sensory nervous system. Recent research has concentrated on the gene expression events downstream of proneural factor function. Here we summarise this research and describe our own research that has provided clear links between a proneural factor, atonal, and the cell biological programme of ciliogenesis, which is a central aspect of sensory neuron differentiation.
Petra I Zur Lage; T Ian Simpson; Andrew Jarman
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-01
Journal Detail:
Title:  Fly     Volume:  5     ISSN:  1933-6942     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-5-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101470897     Medline TA:  Fly (Austin)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
University of Edinburgh; Edinburgh, UK.
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