Document Detail

Linking specification to differentiation: from proneural genes to the regulation of ciliogenesis.
MedLine Citation:
PMID:  21558799     Owner:  NLM     Status:  Publisher    
Much of developmental biology is concerned with the processes by which cells become committed to particular fates in a regulated fashion, whereas cell biology addresses, among other things, the variety of differentiated forms and functions that cells can acquire. One open question is how the regulators of the former process lead to attainment of the latter. 'High-level' regulators of cell fate specification include the proneural factors, which drive cells to commit as precursors in the sensory nervous system. Recent research has concentrated on the gene expression events downstream of proneural factor function. Here we summarise this research and describe our own research that has provided clear links between a proneural factor, atonal, and the cell biological programme of ciliogenesis, which is a central aspect of sensory neuron differentiation.
Petra I Zur Lage; T Ian Simpson; Andrew Jarman
Related Documents :
19768669 - Substrate stiffness affects early differentiation events in embryonic stem cells.
8507559 - Embryonal carcinoma and the basement membrane glycoproteins laminin and entactin.
7918029 - Haem is necessary for a continued increase in ferrochelatase mrna in murine erythroleuk...
19229869 - Exogenous nanog alleviates but is insufficient to reverse embryonic stem cells differen...
20117089 - Mechanical behavior of human mesenchymal stem cells during adipogenic and osteogenic di...
18840279 - Transglutaminase activity in the hematopoietic tissue of a crustacean, pacifastacus len...
9406149 - Expression of fibroblast growth factor receptor-1 in rat heart h9c2 myoblasts increases...
16867869 - Extracellular matrix metalloproteinase inducer in interstitial pneumonias.
23633299 - Siglec-h on activated microglia for recognition and engulfment of glioma cells.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-01
Journal Detail:
Title:  Fly     Volume:  5     ISSN:  1933-6942     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-5-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101470897     Medline TA:  Fly (Austin)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
University of Edinburgh; Edinburgh, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Inactivation kinetics of voltage-gated calcium channels in glutamatergic neurons are influenced by S...
Next Document:  NPMc+ AML cell line shows differential protein expression and lower sensitivity to DNA-damaging and ...