| Linking immune-mediated arterial inflammation and cholesterol-induced atherosclerosis in a transgenic mouse model. | |
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MedLine Citation:
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PMID: 11050173 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Arterial inflammatory responses are thought to be a significant component of atherosclerotic disease. We describe here, using a transgenic approach, the mutual perpetuation of immune-mediated arterial inflammation and cholesterol-induced atherosclerosis. Mice expressing the bacterial transgene beta-galactosidase exclusively in cardiomyocytes and in smooth muscle cells in lung arteries and the aorta (SM-LacZ), and hypercholesterolemic apolipoprotein E-deficient SM-LacZ mice (SM-LacZ/apoE(-/-)) developed myocarditis and arteritis after immunization with dendritic cells presenting a beta-galactosidase-derived immunogenic peptide. Hypercholesterolemia amplified acute arteritis and perpetuated chronic arterial inflammation in SM-LacZ/apoE(-/-) mice, but had no major impact on acute myocarditis or the subsequent development of dilated cardiomyopathy. Conversely, arteritis significantly accelerated cholesterol-induced atherosclerosis. Taken together, these data demonstrate that the linkage of immune-mediated arteritis and hypercholesterolemia favors initiation and maintenance of atherosclerotic lesion formation. Therapeutic strategies to prevent or disrupt such self-perpetuating vicious circles may be crucial for the successful treatment of atherosclerosis. |
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Authors:
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B Ludewig; S Freigang; M Jäggi; M O Kurrer; Y C Pei; L Vlk; B Odermatt; R M Zinkernagel; H Hengartner |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 97 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2000 Nov |
Date Detail:
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Created Date: 2000-11-27 Completed Date: 2001-01-11 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 12752-7 Citation Subset: IM |
Affiliation:
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Institute of Experimental Immunology, Department of Pathology, and Institute for Clinical Chemistry, University Hospital Zurich, University of Zurich, Zurich, Switzerland. ludewigb@pathol.unizh.ch |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta / immunology*, pathology Arteriosclerosis / etiology, immunology*, metabolism Cholesterol / immunology*, metabolism Dendritic Cells / immunology Female Hypercholesterolemia / immunology Male Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Pulmonary Artery / immunology*, pathology |
| Chemical | |
Reg. No./Substance:
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57-88-5/Cholesterol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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