| Linking cellular activation to cytoskeletal reorganization: Wiskott-Aldrich syndrome as a model. | |
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MedLine Citation:
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PMID: 11964736 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Wiskott-Aldrich syndrome is an inherited X-linked disorder characterized by immune deficiency, eczema, and thrombocytopenia with small platelets. The mutated protein, Wiskott-Aldrich syndrome protein, is an activator of actin cytoskeletal reorganization in hematopoietic cells. Members of the Wiskott-Aldrich syndrome protein family are being shown to be key integrators of cell signalling and cytoskeletal organization in many eukaryotic cell types. This review focuses on recent discoveries that reveal in increasing detail how Wiskott-Aldrich syndrome protein and its related proteins operate. |
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Authors:
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D M Stewart; L Tian; D L Nelson |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in allergy and clinical immunology Volume: 1 ISSN: 1528-4050 ISO Abbreviation: Curr Opin Allergy Clin Immunol Publication Date: 2001 Dec |
Date Detail:
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Created Date: 2002-04-19 Completed Date: 2002-06-13 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 100936359 Medline TA: Curr Opin Allergy Clin Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 525-33 Citation Subset: IM |
Affiliation:
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Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. dln@helix.nih.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cytoskeleton
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metabolism* Humans Lymphocyte Activation / immunology* Proteins / genetics, metabolism* Wiskott-Aldrich Syndrome / genetics, immunology, physiopathology* Wiskott-Aldrich Syndrome Protein |
| Chemical | |
Reg. No./Substance:
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0/Proteins; 0/WAS protein, human; 0/Wiskott-Aldrich Syndrome Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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