| Linker-modified triamine-linked acridine dimers: synthesis and cytotoxicity properties in vitro and in vivo. | |
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MedLine Citation:
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PMID: 17107806 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The preparation and cytotoxicity properties of a series of N(epsilon)-substituted triamine-linked acridine dimers are described. Most acridine dimer derivatives reveal highly potent in vitro cytotoxicity properties and DNA binding activity. Several acridine dimers were selected to study their action in vivo. These acridine dimers have demonstrated a narrow safe margin, as has adriamycin, but higher maximum tolerate dose (MTD) in comparison with that of adriamycin in ICR mice. The acridine dimers also demonstrated various anit-COLO 205 solid tumor activities in vivo. Compound 1 has shown the most potent solid tumor inhibition. |
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Authors:
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Shan-Shue Wang; Yi-Jen Lee; Shih-Chung Hsu; Hsueh-O Chang; Wei-Kung Yin; Lien-Shange Chang; Shan-Yen Chou |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-10-28 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry Volume: 15 ISSN: 0968-0896 ISO Abbreviation: Bioorg. Med. Chem. Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2006-12-15 Completed Date: 2007-03-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9413298 Medline TA: Bioorg Med Chem Country: England |
Other Details:
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Languages: eng Pagination: 735-48 Citation Subset: IM |
Affiliation:
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Department of Biochemical Engineering, Kao Yuan University, 1821 Chung-Shan Rd, Lu-Chu Hsiang, Kaohsiung, Taiwan, ROC. sswang@cc.kyu.edu.tw |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acridines
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chemical synthesis*,
pharmacology* Animals Antineoplastic Agents / chemical synthesis*, pharmacology* Cell Line, Tumor Cell Survival / drug effects Colonic Neoplasms / drug therapy, pathology DNA / metabolism Humans Indicators and Reagents Intercalating Agents / chemical synthesis, pharmacology Magnetic Resonance Spectroscopy Mass Spectrometry Mice Mice, Inbred ICR Mice, SCID Nitrogen / chemistry Plasmids / drug effects, genetics Structure-Activity Relationship Tetrazolium Salts Thiazoles |
| Chemical | |
Reg. No./Substance:
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0/Acridines; 0/Antineoplastic Agents; 0/Indicators and Reagents; 0/Intercalating Agents; 0/Tetrazolium Salts; 0/Thiazoles; 298-93-1/thiazolyl blue; 7727-37-9/Nitrogen; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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