| Linkage relationships between DXS105, DXS98, and other polymorphic DNA markers flanking the fragile X locus. | |
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MedLine Citation:
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PMID: 1673310 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report on linkage data between DXS105, DXS98, the locus for the fragile X syndrome (FRAXA), and 3 other polymorphic loci that flank the FRAXA locus. An analysis was undertaken to determine the relative positions of DXS105 and DXS98 and to test the assignment of DXS105 to a location proximal and closely linked to FRAXA. In this study of fragile X fra(X) syndrome families, the DXS105 locus was calculated to be proximal to FRAXA with a maximum lod score of 10.36 at theta = 0.08. DXS105 was also shown to be closely linked to the gene for factor IX (F9)(Z = 11.84 at theta = 0.08) and to DXS98 (Z = 4.91 at theta = 0.04). The order of the loci proximal to FRAXA is most likely centromere-factor IX-DXS105-DXS98-FRAXA-telomere. The use of DXS105 and DXS98 in clinical investigations should significantly increase the accuracy of risk assessment in informative fragile X families. |
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Authors:
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N J Carpenter; S N Thibodeau; W T Brown |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of medical genetics Volume: 38 ISSN: 0148-7299 ISO Abbreviation: Am. J. Med. Genet. Publication Date: 1991 Feb-Mar |
Date Detail:
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Created Date: 1991-05-21 Completed Date: 1991-05-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7708900 Medline TA: Am J Med Genet Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 349-53 Citation Subset: IM |
Affiliation:
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Chapman Research Institute of Medical Genetics, Children's Medical Center, Tulsa, Oklahoma 74135. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chromosome Mapping DNA Probes / diagnostic use* Fragile X Syndrome / genetics* Genetic Markers Humans Lod Score Pedigree Polymorphism, Restriction Fragment Length* Risk X Chromosome |
| Chemical | |
Reg. No./Substance:
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0/DNA Probes; 0/Genetic Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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