Document Detail

Linkage of proximal myotonic myopathy to chromosome 3q.
MedLine Citation:
PMID:  9921867     Owner:  NLM     Status:  MEDLINE    
We performed genetic linkage analysis in nine German proximal myotonic myopathy (PROMM) families using DNA-markers D3S1541 and D3S1589 from the region of the recently discovered gene locus of myotonic dystrophy type 2 (DM2) on chromosome 3q. Two-point analysis supplied an lod score of 5.9. We conclude that a gene causing PROMM is located on chromosome 3q. PROMM and DM2 may be allelic disorders or may be caused by closely linked genes.
K Ricker; T Grimm; M C Koch; C Schneider; W Kress; C D Reimers; W Schulte-Mattler; B Mueller-Myhsok; K V Toyka; C R Mueller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurology     Volume:  52     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-02-04     Completed Date:  1999-02-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  170-1     Citation Subset:  AIM; IM    
Department of Neurology, University of Würzburg, Germany.
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MeSH Terms
Chromosome Mapping
Chromosomes, Human, Pair 3*
Genetic Markers
Linkage (Genetics)*
Myotonia / genetics*
Reg. No./Substance:
0/Genetic Markers
Comment In:
Neurology. 1999 Jan 1;52(1):12-3   [PMID:  9921841 ]

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