Document Detail


Linkage mapping of melanoma (MLM) using 172 microsatellite markers.
MedLine Citation:
PMID:  1478674     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The incidence of malignant melanoma is currently increasing faster than any other cancer and in 5-12% of cases occurs in a familial context in which the disease cosegregates as an autosomal dominant trait. To identify the location of genes that predipose individuals to familial melanoma (MLM), we have carried out linkage analysis in three large Australian melanoma pedigrees using 172 microsatellite markers spread across all autosomes. Three additional smaller families were typed for 70 of the same markers. In five of the six families we found lod scores between 1.0 and 2.3, which may provide evidence for the location of melanoma genes in proximity to some of these markers. If this turns out to be the case, these data potentially demonstrate that MLM is genetically heterogeneous since there was no marker for which all families gave significantly high LODs. These data provide the foundation for an exclusion map for melanoma and, more importantly, high-light areas of the genome for others to substantiate the potential positions of some of the genes that may be responsible for susceptibility to MLM.
Authors:
D J Nancarrow; G J Walker; J L Weber; M K Walters; J M Palmer; N K Hayward
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genomics     Volume:  14     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-02-10     Completed Date:  1993-02-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  939-47     Citation Subset:  IM    
Affiliation:
Queensland Cancer Fund Research Unit, Queensland Institute of Medical Research, Herston, Australia.
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MeSH Terms
Descriptor/Qualifier:
Chromosome Mapping
DNA, Satellite / genetics*
Female
Genetic Markers
Genetic Predisposition to Disease
Humans
Linkage (Genetics)*
Lod Score
Male
Melanoma / genetics*
Pedigree
Chemical
Reg. No./Substance:
0/DNA, Satellite; 0/Genetic Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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