Document Detail


Linkage mapping in populations with karyotypic rearrangements.
MedLine Citation:
PMID:  11218078     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A simulation study was used to examine the consequences of karyotypic rearrangements on molecular genetic map construction. Two groups of 50 datasets were created for F2 populations segregating for a reciprocal translocation of chromosomal segments or a reciprocal translocation and inversion. Multiple attempts were made to construct maps for each dataset using MapMaker/EXP. As expected, the markers from segments involved in the translocation formed one linkage group. Maps that corresponded to the known marker order within a segment could be constructed by the following method. The separation of markers distal to the translocation breakpoints into their respective segments could be made by constructing multiple maps, using distinct orders of marker entry, and observing the variances in intermarker distances: variances between pairs of markers from the same segment were an order of magnitude less compared to pairs where markers were from different segments. The order of markers within a segment could be determined from combining the pairwise linkage results from multiple maps, or from maps including all markers from a segment. No bias in map distances was observed. These results indicate that, under conditions similar to those tested, genetic maps corresponding to the segments conserved in translocations can be constructed.
Authors:
K D Livingstone; G Churchill; M K Jahn
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of heredity     Volume:  91     ISSN:  0022-1503     ISO Abbreviation:  J. Hered.     Publication Date:    2000 Nov-Dec
Date Detail:
Created Date:  2001-02-19     Completed Date:  2001-05-24     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0375373     Medline TA:  J Hered     Country:  United States    
Other Details:
Languages:  eng     Pagination:  423-8     Citation Subset:  IM    
Affiliation:
Department of Plant Breeding and Biometry, Cornell University, Ithaca, NY 14853, USA. klivings@bio.indiana.edu
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MeSH Terms
Descriptor/Qualifier:
Chromosome Inversion*
Chromosome Mapping
Computer Simulation*
Databases, Factual
Genetic Markers
Humans
Karyotyping
Linkage (Genetics)*
Models, Genetic*
Translocation, Genetic*
Chemical
Reg. No./Substance:
0/Genetic Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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