Document Detail


Linkage mapping and fluorescence in situ hybridization of TCTE1 on human chromosome 6p: analysis of dinucleotide polymorphisms on native gels.
MedLine Citation:
PMID:  1916824     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Highly informative dinucleotide repeat polymorphisms were identified at the T-complex-associated-testes-expressed-1 (TCTE1) locus on human chromosome 6p. Electrophoresis of single-stranded DNA on native gels facilitated the analysis of the dinucleotide polymorphisms. Linkage mapping positions this marker midway between the centromere and HLA with recombination fractions as follows: D6Z1-0.21-TCTE1-0.24-HLA. Two-color fluorescence in situ hybridization places TCTE1 proximal to CRIL171 (D6S19). Together, linkage and in situ hybridization indicate that the order of the loci is D6Z1-D6S4-D6S90-TCTE1-D6S19-D6S29-HL A-telomere. A sequence tagged site (STS) was established, and three yeast artificial chromosome (YAC) clones were identified for the TCTE1 locus.
Authors:
T J Kwiatkowski; A L Beaudet; B J Trask; H Y Zoghbi
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genomics     Volume:  10     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-11-04     Completed Date:  1991-11-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  921-6     Citation Subset:  IM    
Affiliation:
Institute for Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030.
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MeSH Terms
Descriptor/Qualifier:
African Continental Ancestry Group
Alleles
Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 6*
Cloning, Molecular
DNA / genetics
Dinucleoside Phosphates / analysis*
European Continental Ancestry Group
Female
Gene Frequency
Humans
Linkage (Genetics)*
Male
Microscopy, Fluorescence
Molecular Sequence Data
Nucleic Acid Hybridization
Oligodeoxyribonucleotides
Polymerase Chain Reaction
Polymorphism, Genetic*
Repetitive Sequences, Nucleic Acid
United States
Grant Support
ID/Acronym/Agency:
HD-17665/HD/NICHD NIH HHS; HD00684/HD/NICHD NIH HHS; NS27699/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Dinucleoside Phosphates; 0/Oligodeoxyribonucleotides; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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