Document Detail


Linkage disequilibrium and recombination rate estimates in the self-incompatibility region of Arabidopsis lyrata.
MedLine Citation:
PMID:  17565949     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Genetic diversity is unusually high at loci in the S-locus region of the self-incompatible species of the flowering plant, Arabidopsis lyrata, not just in the S loci themselves, but also at two nearby loci. In a previous study of a single natural population from Iceland, we attributed this elevated polymorphism to linkage disequilibrium (LD) between variants at loci close to the S locus and the S alleles, which are maintained in the population by balancing selection. With the four S-flanking loci whose diversity we previously studied, we could not determine the extent of the region linked to the S loci in which neutral sites are affected. We also could not exclude the possibility of a population bottleneck, or of admixture, as causes of the LD. We have now studied four more distant loci flanking the S-locus region, and more populations, and we analyze the results using a theoretical model of the effect of balancing selection on diversity at linked neutral sites within and between different functional S-allelic classes. In the model, diversity is a function of the number of selectively maintained alleles and the recombination distances from the selectively maintained sites. We use the model to estimate the number of different functional S alleles, their turnover rate, and recombination rates between the S-locus region and other loci. Our estimates suggest that there is a small region of very low recombination surrounding the S-locus region.
Authors:
Esther Kamau; Brian Charlesworth; Deborah Charlesworth
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-11
Journal Detail:
Title:  Genetics     Volume:  176     ISSN:  0016-6731     ISO Abbreviation:  Genetics     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-24     Completed Date:  2007-12-06     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  0374636     Medline TA:  Genetics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2357-69     Citation Subset:  IM    
Affiliation:
Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, W. Mains Road, Edinburgh, United Kingdom.
Data Bank Information
Bank Name/Acc. No.:
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MeSH Terms
Descriptor/Qualifier:
Alleles
Arabidopsis / genetics*
Base Sequence
DNA Primers / genetics
DNA, Plant / genetics
Genes, Plant
Genetic Variation
Genetics, Population
Iceland
Linkage Disequilibrium
Models, Genetic
Molecular Sequence Data
Polymorphism, Genetic
Recombination, Genetic
Chemical
Reg. No./Substance:
0/DNA Primers; 0/DNA, Plant
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