Document Detail


Linkage analysis of the human HMG14 gene on chromosome 21 using a GT dinucleotide repeat as polymorphic marker.
MedLine Citation:
PMID:  1970797     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A (GT)n repeat in intron 4 of the functional human HMG14 gene on chromosome 21 was used as polymorphic marker to map this gene relative to the genetic linkage map of human chromosome 21. Variation in the length of the (GT)n repeat was detected by electrophoresis on polyacrylamide gels of DNA amplified by the polymerase chain reaction using primers flanking the repeat. The observed heterozygosity of this polymorphism in 40 CEPH families was 58% with six different alleles. Linkage analysis localized the HMG14 gene close to the ETS2 gene and locus D21S3 in chromosomal band 21q22.3.
Authors:
M B Petersen; E P Economou; S A Slaugenhaupt; A Chakravarti; S E Antonarakis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genomics     Volume:  7     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-06-08     Completed Date:  1990-06-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  136-8     Citation Subset:  IM    
Affiliation:
Center for Medical Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
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MeSH Terms
Descriptor/Qualifier:
Chromosomes, Human, Pair 21*
Electrophoresis, Polyacrylamide Gel
Female
Genes
Genetic Markers
High Mobility Group Proteins / genetics*
Humans
Introns
Linkage (Genetics)*
Male
Pedigree
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Repetitive Sequences, Nucleic Acid*
Grant Support
ID/Acronym/Agency:
GM33771/GM/NIGMS NIH HHS; HD00774/HD/NICHD NIH HHS; R01 HD19591/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Genetic Markers; 0/High Mobility Group Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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