Document Detail


Linkage analysis of glomerular filtration rate in American Indians.
MedLine Citation:
PMID:  18854848     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
American Indians have a disproportionately high rate of kidney disease likely due to a combination of environmental and genetic factors. We performed a genome wide scan of estimated glomerular filtration rate in 3665 participants of the Strong Heart Family Study to localize genes influencing kidney disease risk factors. The participants were men and women from 13 American Indian tribes recruited from 3 centers located in Arizona, the Dakotas and Oklahoma. Multipoint variance component linkage analysis was performed for each center and on the entire cohort after controlling for center effects. Modeling strategies that incorporated age, gender and interaction terms (model 1) and another that also controlled for diabetes mellitus, systolic and diastolic blood pressure, body mass index, low density and high density lipoproteins, triglycerides and smoking status (model 2) were used. Significant evidence for linkage in the Arizona group was found on chromosome 12p12.2 at 39cM (nearest marker D12S310) using model 1. Additional loci with very suggestive evidence for linkage were detected at 1p36.31 for all groups using both models and at 2q33.3 and 9q34.2 for the Dakotas group each using model 1. No significant evidence for additive interaction with diabetes, hypertension or obesity was noted. This evidence for linkage of a quantitative trait locus influencing estimated glomerular filtration rate to a region of chromosome 12p in a large cohort of American Indians will be worth studying in more detail in the future.
Authors:
Amy K Mottl; Suma Vupputuri; Shelley A Cole; Laura Almasy; Harald H H Göring; Vincent P Diego; Sandra Laston; Nora Franceschini; Nawar M Shara; Elisa T Lee; Lyle G Best; Richard R Fabsitz; Jean W MacCluer; Jason G Umans; Kari E North
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural     Date:  2008-08-13
Journal Detail:
Title:  Kidney international     Volume:  74     ISSN:  1523-1755     ISO Abbreviation:  Kidney Int.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-15     Completed Date:  2009-01-12     Revised Date:  2014-04-24    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1185-91     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Chromosome Mapping
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 2
Chromosomes, Human, Pair 9
Family Health
Female
Genetic Linkage*
Glomerular Filtration Rate / genetics*
Humans
Indians, North American / genetics*
Kidney Diseases / genetics*
Male
Middle Aged
Phenotype
Quantitative Trait Loci / genetics
Quantitative Trait, Heritable
Risk Factors
Young Adult
Grant Support
ID/Acronym/Agency:
MH059490/MH/NIMH NIH HHS; U01 HL041642/HL/NHLBI NIH HHS; U01 HL041642-20/HL/NHLBI NIH HHS; U01 HL041652-17/HL/NHLBI NIH HHS; U01 HL041654/HL/NHLBI NIH HHS; U01 HL041654-20/HL/NHLBI NIH HHS; U01 HL065520/HL/NHLBI NIH HHS; U01 HL065520-08/HL/NHLBI NIH HHS; U01 HL065521/HL/NHLBI NIH HHS; U01 HL065521-08/HL/NHLBI NIH HHS; U01 HL41642/HL/NHLBI NIH HHS; U01 HL41652/HL/NHLBI NIH HHS; U01 HL41654/HL/NHLBI NIH HHS; U01 HL65520/HL/NHLBI NIH HHS; U01 HL65521/HL/NHLBI NIH HHS
Comments/Corrections
Comment In:
Kidney Int. 2008 Nov;74(9):1109-12   [PMID:  18854845 ]

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