Document Detail

Linkage analysis of 62 X-chromosomal loci excludes the X chromosome in an Icelandic family showing apparent X-linked recessive inheritance of neural tube defects.
MedLine Citation:
PMID:  8076409     Owner:  NLM     Status:  MEDLINE    
We report here the findings of a linkage analysis, involving numerous markers from the human X chromosome, in an attempt to localise a putative gene causing apparent X-linked spina bifida and anencephaly (SBA) in a large Icelandic pedigree. Two-point linkage analysis was performed using markers from 62 informative loci in this family. Although small positive lod scores were found at a number of these loci, none reached the significance level for linkage. Haplotypes were extensively analysed and found to exclude linkage to the X chromosome.
R Newton; P Stanier; S Loughna; D J Henderson; S A Forbes; M Farrall; O Jensson; G E Moore
Related Documents :
1203429 - Tests for association of gene frequencies at several loci in random mating diploid popu...
8886169 - Linkage disequilibrium analysis of g-olf alpha (gnal) in bipolar affective disorder.
8930079 - Alignment of the pigmap and usda linkage maps of porcine chromosomes 3 and 9.
15113729 - A genome-wide linkage scan for dietary energy and nutrient intakes: the health, risk fa...
16741189 - Novel genomic loci influencing plasma homocysteine levels.
16385469 - A tree-based model for allele-sharing-based linkage analysis in human complex diseases.
18702679 - Variations in the promoter of cyp21a2 gene identified in a chinese patient with simple ...
7722339 - Electrophoretic karyotype of intracellular yeast-like symbiotes in rice planthoppers an...
1420939 - Dynamics of benzo[a]pyrene diol epoxide adducts in poly(dg-dc).(dg-dc) studied by synch...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical genetics     Volume:  45     ISSN:  0009-9163     ISO Abbreviation:  Clin. Genet.     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-10-04     Completed Date:  1994-10-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0253664     Medline TA:  Clin Genet     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  241-9     Citation Subset:  IM    
Action Research Laboratory for the Molecular Biology of Fetal Development, Royal Postgraduate Medical School, London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Base Sequence
Chromosome Mapping
Linkage (Genetics)
Middle Aged
Molecular Sequence Data
Neural Tube Defects / genetics*
Polymerase Chain Reaction
X Chromosome*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  DNA carrier detection in X-linked progressive cone dystrophy.
Next Document:  Increased frequency of apolipoprotein B signal peptide sp24/24 in patients with coronary artery dise...