| Link between traditional cardiovascular risk factors and inflammation in early arthritis patients. | |
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MedLine Citation:
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PMID: 22275176 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the characteristics of traditional cardiovascular risk factors of untreated early arthritis (EA) patients and healthy subjects, and to look for a link between cardiovascular risk factors and inflammation in EA patients. METHODS: This Multicentre case-control study enrolled 607 EA patients (ESPOIR cohort) and 1821 age- and gender-matched controls (WHO MONICA survey). Lipid levels, blood pressure, glucose levels and exposure to smoking were characterized in patients and controls. Systemic inflammation was quantified in EA patients. Traditional cardiovascular risk factors characteristics were compared between EA patients and controls. The link between cardiovascular risk factors and inflammation was assessed in EA patients. RESULTS: Mean (standard error of the mean) total cholesterol 2.14 (0.022) vs 2.34 (0.017) g/l (p<0.001), HDL cholesterol 0.60 (0.011) vs 0.63 (0.007) (p=0.020), and LDL cholesterol 1.28 (0.025) vs 1.51 (0.016) g/l (p<0.001), were lower in EA patients than in controls. Triglycerides, triglyceride/HDL ratio and pulse pressure were higher in EA patients. Diastolic blood pressure and glucose levels were lower in EA patients. Former or current smokers were more frequent in EA patients. Total and HDL cholesterol levels were negatively associated with CRP or serum interleukin-6 levels. CONCLUSION: Total, HDL and LDL cholesterol, triglycerides, diastolic blood pressure, pulse pressure, glucose and triglyceride/HDL ratio differ between EA patients and controls. Some of these risk factors appear to be linked to systemic inflammation. Such initial differences could modulate the risk of cardiovascular events later in the course of arthritis. © 2012 by the American College of Rheumatology. |
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Authors:
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Jean-Frédéric Boyer; Vanina Bongard; Alain Cantagrel; Bénédicte Jamard; Jacques-Eric Gottenberg; Xavier Mariette; Jean-Luc Davignon; Jean Ferrières; Jean-Bernard Ruidavets; Jean Dallongeville; Dominique Arveiler; Anne Cambon-Thomsen; Arnaud Constantin |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-24 |
Journal Detail:
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Title: Arthritis care & research Volume: - ISSN: 2151-4658 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101518086 Medline TA: Arthritis Care Res (Hoboken) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 by the American College of Rheumatology. |
Affiliation:
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Department of Rheumatology, Centre Hospitalier Universitaire de Toulouse, Toulouse, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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