Document Detail

Link between pregnancy complications and minor physical anomalies in monozygotic twins discordant for schizophrenia.
MedLine Citation:
PMID:  8037254     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of the current study was to explore the relevancy of early pregnancy complications for the development of minor physical anomalies in monozygotic twins discordant and concordant for schizophrenia. METHOD: Pregnancy complications and minor physical anomalies were independently assessed in 22 discordant, 10 concordant, and six normal comparison monozygotic twin pairs. RESULTS: Complications occurring during early pregnancy were associated with a higher frequency of minor physical anomalies in the total group and in the discordant twin pairs particularly. While no significant differences in anomaly rates were observed among the discordant, concordant, and normal comparison groups, the discordant ill twins showed a trend toward having more anomalies than their well co-twins. CONCLUSIONS: Complications occurring early in pregnancy are relevant for the development of minor physical anomalies and may be of particular importance for the development of these anomalies in twin pairs discordant for schizophrenia.
E Cantor-Graae; T F McNeil; E F Torrey; P Quinn; A Bowler; K Sjöström; R Rawlings
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of psychiatry     Volume:  151     ISSN:  0002-953X     ISO Abbreviation:  Am J Psychiatry     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1994-08-15     Completed Date:  1994-08-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370512     Medline TA:  Am J Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1188-93     Citation Subset:  AIM; IM    
Department of Psychiatry, Lund University, Sweden.
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MeSH Terms
Congenital Abnormalities / epidemiology,  etiology,  genetics*
Diseases in Twins / epidemiology,  genetics*
Ear, External / abnormalities
Pregnancy Complications / epidemiology*
Pregnancy Trimester, First
Pregnancy Trimester, Second
Schizophrenia / epidemiology,  etiology,  genetics*
Twins, Monozygotic
Grant Support

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