| Link between pregnancy complications and minor physical anomalies in monozygotic twins discordant for schizophrenia. | |
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MedLine Citation:
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PMID: 8037254 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of the current study was to explore the relevancy of early pregnancy complications for the development of minor physical anomalies in monozygotic twins discordant and concordant for schizophrenia. METHOD: Pregnancy complications and minor physical anomalies were independently assessed in 22 discordant, 10 concordant, and six normal comparison monozygotic twin pairs. RESULTS: Complications occurring during early pregnancy were associated with a higher frequency of minor physical anomalies in the total group and in the discordant twin pairs particularly. While no significant differences in anomaly rates were observed among the discordant, concordant, and normal comparison groups, the discordant ill twins showed a trend toward having more anomalies than their well co-twins. CONCLUSIONS: Complications occurring early in pregnancy are relevant for the development of minor physical anomalies and may be of particular importance for the development of these anomalies in twin pairs discordant for schizophrenia. |
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Authors:
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E Cantor-Graae; T F McNeil; E F Torrey; P Quinn; A Bowler; K Sjöström; R Rawlings |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of psychiatry Volume: 151 ISSN: 0002-953X ISO Abbreviation: Am J Psychiatry Publication Date: 1994 Aug |
Date Detail:
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Created Date: 1994-08-15 Completed Date: 1994-08-15 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370512 Medline TA: Am J Psychiatry Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1188-93 Citation Subset: AIM; IM |
Affiliation:
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Department of Psychiatry, Lund University, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Comorbidity Congenital Abnormalities / epidemiology, etiology, genetics* Diseases in Twins / epidemiology, genetics* Ear, External / abnormalities Female Humans Male Pregnancy Pregnancy Complications / epidemiology* Pregnancy Trimester, First Pregnancy Trimester, Second Prevalence Schizophrenia / epidemiology, etiology, genetics* Twins, Monozygotic |
| Grant Support | |
ID/Acronym/Agency:
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NIMH MH-41176/MH/NIMH NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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