Document Detail


Link between interleukin-10 level and outcome after ischemic stroke.
MedLine Citation:
PMID:  20203528     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The prognostic value of interleukin (IL)-10 in patients after acute ischemic stroke (IS) is not well understood. This study tested the hypothesis that serum levels of IL-10 are substantially increased after IS and predictive of IS outcome. METHODS: Serum IL-10 levels were examined 48 h after acute IS in 135 consecutive patients, and in 20 healthy and 30 at-risk controls. RESULTS: Mean serum IL-10 was significantly higher in IS patients than in both control groups (p < 0.0001, respectively). Additionally, serum IL-10 was significantly higher in patients with severe neurological impairment [defined as a score >or=12 on the National Institute of Health Stroke Scale (NIHSS)] than in patients with less severe neurological impairment (NIHSS score <12) 48 h after IS (p < 0.0001). Furthermore, higher serum IL-10 was strongly and independently correlated with severe neurological impairment (NIHSS >or=12) 48 h after acute IS (p < 0.0001), and independently predictive of combined major adverse clinical outcomes (defined as recurrent IS, any cause of death or NIHSS >or=12) on day 90 following IS (p < 0.0001). CONCLUSIONS: Serum IL-10 is an independent prognosticator of IS outcome.
Authors:
Li-Teh Chang; Chun-Man Yuen; Chia-Wei Liou; Cheng-Hsien Lu; Wen-Neng Chang; Ali A Youssef; Hon-Kan Yip
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Publication Detail:
Type:  Journal Article     Date:  2010-03-05
Journal Detail:
Title:  Neuroimmunomodulation     Volume:  17     ISSN:  1423-0216     ISO Abbreviation:  Neuroimmunomodulation     Publication Date:  2010  
Date Detail:
Created Date:  2010-03-24     Completed Date:  2010-06-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9422763     Medline TA:  Neuroimmunomodulation     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  223-8     Citation Subset:  IM    
Affiliation:
Division of Basic Medical Science, Department of Nursing, Meiho Institute of Technology, Ping Tung, Taiwan, ROC.
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MeSH Terms
Descriptor/Qualifier:
Aged
Biological Markers / blood
Brain Ischemia / blood*,  diagnosis,  immunology*
Encephalitis / blood,  diagnosis,  immunology
Female
Humans
Interleukin-10 / analysis,  blood*
Male
Middle Aged
Outcome Assessment (Health Care)
Predictive Value of Tests
Prognosis
Recovery of Function / immunology
Stroke / blood*,  diagnosis,  immunology*
Up-Regulation / immunology
Chemical
Reg. No./Substance:
0/Biological Markers; 130068-27-8/Interleukin-10

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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