Document Detail


Linguistic, psychometric validation and diagnostic ability assessment of an Italian version of a 19-item wearing-off questionnaire for wearing-off detection in Parkinson's disease.
MedLine Citation:
PMID:  22307444     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A patient self-rated 19-item wearing-off questionnaire (WOQ-19) was shown to be a potent screening tool for wearing-off (WO) in patients with Parkinson's disease. As part of the early detection of wearing-off in Parkinson's disease study, we preliminarily performed a linguistic and a psychometric validation of an Italian version of the WOQ-19. Moreover, we assessed the sensitivity and specificity of the WOQ-19 in the office-based settings. The psychometric validation study included assessment of discriminant ability, internal consistency and test-retest reliability. The intraclass correlation coefficient (ICC) and the Cronbach's Alpha were assessed. The WOQ-19 sensitivity and specificity were calculated in respect to the physician assessment of WO, taken as the gold standard. The Italian version of WOQ-19 was found easy to understand by ≥80% of the patients. The number of WO-related symptoms detected by WOQ-19 was 7.5 ± 3.2 in patients with WO and 1.6 ± 2.6 in patients without WO (p < 0.0001). Cronbach's alpha was equal to 0.868 for the total number of WO symptoms. The ICC value was equal to 0.858 for WO-related symptoms as a whole. The diagnostic ability study recruited 207 patients: for a WOQ-19 cut-off ≥2, the sensitivity was equal to 0.881 and the specificity was 0.674. This is the first validation of WOQ-19 in Italian, with excellent linguistic validity and psychometric properties. WOQ-19 was confirmed to be reliable in WO detection.
Authors:
Giovanni Abbruzzese; Angelo Antonini; Paolo Barone; Fabrizio Stocchi; Tiziano Tamburini; Laura Bernardi; Marianna Amboni; Laura Vacca; Valeria Posocco; Delia Colombo
Related Documents :
16649384 - Abdominal pain due to lead-contaminated opium: a new source of inorganic lead poisoning...
24949444 - Are proteinase 3 and cathepsin c enzymes related to pathogenesis of periodontitis?
20129624 - Seasonal postpartum hypernatremic encephalopathy with osmotic extrapontine myelinolysis...
7966524 - Pathophysiology and treatment of carbon monoxide poisoning.
17153694 - Comparison between secretory leukocytic protease inhibitor and reactive nitrogen interm...
24943134 - Unmasked brugada pattern by ajmaline challenge in patients with myotonic dystrophy type 1.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-4
Journal Detail:
Title:  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology     Volume:  -     ISSN:  1590-3478     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100959175     Medline TA:  Neurol Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Neurosciences, University of Genoa, Genoa, Italy, 29812@unige.it.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Patterns of Adolescents' Beliefs About Fighting and Their Relation to Behavior and Risk Factors for ...
Next Document:  Wernekink commissure syndrome: a rare midbrain syndrome.