Document Detail

Linezolid: a new antibiotic for newborns and children?
MedLine Citation:
PMID:  17267334     Owner:  NLM     Status:  MEDLINE    
Staphylococcus aureus remains one of the most common and troublesome microorganisms causing disease in humans, despite the development of effective antibiotics. Linezolid is a member of a new class of synthetic antibiotics called oxazolidinones, introduced into therapy due to the increasing resistance of Gram-positive pathogens to traditional antibiotics. Information about the pharmacokinetics and tolerability profile of linezolid in the pediatric population mostly derive from adult studies and especially in the neonatal field relatively few data are available. Here we summarize linezolid's characteristics and report data available in the literature regarding linezolid use in newborns and children. For this purpose, a Medline search was performed between 1990 and 2006 involving the term "linezolid" combined with the terms "newborn", "infant", "child", "pediatrics". Additional information was obtained from Reactions Weekly.
L Cuzzolin; V Fanos
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of chemotherapy (Florence, Italy)     Volume:  18     ISSN:  1120-009X     ISO Abbreviation:  J Chemother     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2007-02-01     Completed Date:  2007-03-12     Revised Date:  2009-08-04    
Medline Journal Info:
Nlm Unique ID:  8907348     Medline TA:  J Chemother     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  573-81     Citation Subset:  IM    
Department of Medicine & Public Health, University of Verona, Italy.
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MeSH Terms
Acetamides / adverse effects,  therapeutic use*
Anti-Infective Agents / adverse effects,  therapeutic use
Bacterial Infections / drug therapy*
Child, Preschool
Cross Infection / drug therapy
Infant, Newborn
Oxazolidinones / adverse effects,  therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Acetamides; 0/Anti-Infective Agents; 0/Oxazolidinones; 165800-03-3/linezolid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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