Document Detail


Linezolid-associated peripheral and optic neuropathy, lactic acidosis, and serotonin syndrome.
MedLine Citation:
PMID:  17655517     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Linezolid is an oxazolidinone antibacterial agent indicated for serious gram-positive infections. Only minor adverse effects were seen in phase III trials. However, more serious adverse effects were reported after commercial release, including cases of lactic acidosis, peripheral and optic neuropathy, and serotonin syndrome. Peripheral and optic neuropathy was usually seen after several months of linezolid therapy (median 5 mo), lactic acidosis after several weeks (median 6 wks), and serotonin syndrome after several days (median 4 days). Death occurred in two of seven reported cases of lactic acidosis, and three of 15 reported cases of serotonin syndrome. Improvement or complete recovery occurred in all cases of optic neuropathy, whereas complete recovery failed to occur in any patient with peripheral neuropathy. Linezolid should be discontinued immediately in patients experiencing these adverse effects. Patients receiving linezolid for more than 28 days should be monitored for signs of peripheral and optic neuropathy.
Authors:
Masashi Narita; Brian T Tsuji; Victor L Yu
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Pharmacotherapy     Volume:  27     ISSN:  0277-0008     ISO Abbreviation:  Pharmacotherapy     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-27     Completed Date:  2007-10-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8111305     Medline TA:  Pharmacotherapy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1189-97     Citation Subset:  IM    
Affiliation:
Infectious Disease Section, University of Pittsburgh, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania 15240, USA.
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MeSH Terms
Descriptor/Qualifier:
Acetamides / administration & dosage,  adverse effects*
Acidosis, Lactic / chemically induced*,  physiopathology
Anti-Infective Agents / administration & dosage,  adverse effects*
Drug Interactions
Female
Humans
Male
Optic Nerve Diseases / chemically induced*,  physiopathology
Oxazolidinones / administration & dosage,  adverse effects*
Peripheral Nervous System Diseases / chemically induced*,  physiopathology
Risk Factors
Serotonin Syndrome / chemically induced,  physiopathology
Serotonin Uptake Inhibitors / adverse effects
Chemical
Reg. No./Substance:
0/Acetamides; 0/Anti-Infective Agents; 0/Oxazolidinones; 0/Serotonin Uptake Inhibitors; 165800-03-3/linezolid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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