| Linezolid activity against disseminated Listeria monocytogenes meningitis and central nervous system abscesses: focus on early drug myelotoxicity. | |
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MedLine Citation:
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PMID: 18690960 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A very infrequent report of Listeria monocytogenes meningitis and multiple subtentorial abscesses (cerebellar, bulbar, and pontine in location), occurred in an immunocompetent man, and is described and discussed on the ground of the most recent literature evidences regarding the frequency, presentation, and outcome of this disease. The possibility to resort to combination linezolid therapy in patients who appear to be not responsive to first-line treatment of cerebral abscess of definite origin, and the appearance of anemia as an early untoward event of this novel oxazolidinone antibiotic, are also debated. |
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Authors:
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Roberto Manfredi |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Current drug safety Volume: 2 ISSN: 1574-8863 ISO Abbreviation: - Publication Date: 2007 May |
Date Detail:
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Created Date: 2008-08-11 Completed Date: 2008-09-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101270895 Medline TA: Curr Drug Saf Country: Unknown |
Other Details:
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Languages: eng Pagination: 141-5 Citation Subset: IM |
Affiliation:
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Department of Clinical and Experimental Medicine, Division of Infectious Diseases, Alma Mater Studiorum University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy. Roberto.manfredi@unibo.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetamides
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adverse effects*,
therapeutic use* Anemia / chemically induced Anti-Infective Agents / adverse effects*, therapeutic use* Brain Abscess / drug therapy*, microbiology Brain Stem / microbiology, radiography Cerebellar Diseases / drug therapy, microbiology Humans Immunocompetence Magnetic Resonance Imaging Male Meningitis, Listeria / drug therapy*, microbiology Middle Aged Oxazolidinones / adverse effects*, therapeutic use* Thienamycins / adverse effects, therapeutic use Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Acetamides; 0/Anti-Infective Agents; 0/Oxazolidinones; 0/Thienamycins; 165800-03-3/linezolid; 96036-03-2/meropenem |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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