Document Detail

Linear scleroderma along Blaschko's lines in a patient with systematized morphea.
MedLine Citation:
PMID:  14609105     Owner:  NLM     Status:  MEDLINE    
We have previously shown that frontoparietal scleroderma en coup de sabre, a type of linear scleroderma that affects the face and scalp, follows the lines of Blaschko, but the question whether linear scleroderma that occurs in the limbs follows Blaschko's lines has not been answered. We describe the case of a 4-year-old girl with multiple morphea showing remarkable unilateral systematized distribution and whose linear lesions in the limbs appeared to follow Blaschko's lines. We suggest that linear scleroderma of the limbs, as well as frontoparietal scleroderma, may occur along the lines of Blaschko. Since both the unilateral distribution and the lesions along Blaschko's lines are the patterns created by genetic mosaicism, we suggest that a significant part of linear scleroderma and perhaps a smaller part of multiple morphea could be related to cutaneous mosaicism.
Yoshinao Soma; Tamihiro Kawakami; Emiko Yamasaki; Rikako Sasaki; Masako Mizoguchi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  83     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  2003  
Date Detail:
Created Date:  2003-11-11     Completed Date:  2004-03-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  362-4     Citation Subset:  IM    
Department of Dermatology, St. Marianna University School of Medicine, Kawasaki, Japan.
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MeSH Terms
Adrenal Cortex Hormones / therapeutic use
Anti-Inflammatory Agents / therapeutic use
Child, Preschool
Scleroderma, Localized / drug therapy,  physiopathology*
Skin / embryology,  physiopathology*
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Anti-Inflammatory Agents

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