Document Detail


Linear and ponderal growth trajectories in well-nourished, iron-sufficient infants are unimpaired by iron supplementation.
MedLine Citation:
PMID:  19776186     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Iron deficiency remains the most common nutritional deficiency worldwide and supplementation is recommended during periods of high risk, including infancy. However, questions have been raised about possible adverse effects of iron on growth in iron-sufficient (IS) infants and the advisability of across-the-board iron supplementation. This study examined whether short- or long-term growth was impaired in IS infants who received iron supplementation. From a longitudinal study of healthy, breast-fed, low- to middle-income Chilean infants randomly assigned to iron supplementation or usual nutrition at 6 or 12 mo, we retrospectively identified infants meeting criteria for iron sufficiency at the time of random assignment (n = 273). Using multilevel analysis, ponderal and linear growth were modeled before, during, and after iron supplementation up to 10 y in 3 comparisons: 1) iron supplementation compared with usual nutrition from 6 to 12 mo; 2) iron supplementation compared with usual nutrition from 12 to 18 mo; and 3) 15 mg/d of iron as drops compared with iron-fortified formula (12 mg/L). Growth trajectories did not differ during or after supplementation indicating no adverse effect of iron in any comparison. These results suggest that, at least in some environments, iron does not impair growth in IS infants.
Authors:
Sheila Gahagan; Sunkyung Yu; Niko Kaciroti; Marcela Castillo; Betsy Lozoff
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-09-23
Journal Detail:
Title:  The Journal of nutrition     Volume:  139     ISSN:  1541-6100     ISO Abbreviation:  J. Nutr.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-21     Completed Date:  2010-01-06     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2106-12     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anemia, Iron-Deficiency / epidemiology,  prevention & control
Body Height
Body Weight
Chile
Dietary Supplements*
Female
Food Additives / pharmacology*
Growth / physiology*
Humans
Infant
Iron / metabolism*,  pharmacology*
Longitudinal Studies
Male
Reference Values
Retrospective Studies
Urban Population
World Health
World Health Organization
Grant Support
ID/Acronym/Agency:
2R01 HD33487-11/HD/NICHD NIH HHS; K23 HD001481/HD/NICHD NIH HHS; K23 HD001481/HD/NICHD NIH HHS; R01 HD033487/HD/NICHD NIH HHS; R01 HD33487/HD/NICHD NIH HHS; R01 HL088530/HL/NHLBI NIH HHS; R01 HL088530/HL/NHLBI NIH HHS; R01 HL088530-05/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Food Additives; E1UOL152H7/Iron
Comments/Corrections

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