| Linear and ponderal growth trajectories in well-nourished, iron-sufficient infants are unimpaired by iron supplementation. | |
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MedLine Citation:
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PMID: 19776186 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Iron deficiency remains the most common nutritional deficiency worldwide and supplementation is recommended during periods of high risk, including infancy. However, questions have been raised about possible adverse effects of iron on growth in iron-sufficient (IS) infants and the advisability of across-the-board iron supplementation. This study examined whether short- or long-term growth was impaired in IS infants who received iron supplementation. From a longitudinal study of healthy, breast-fed, low- to middle-income Chilean infants randomly assigned to iron supplementation or usual nutrition at 6 or 12 mo, we retrospectively identified infants meeting criteria for iron sufficiency at the time of random assignment (n = 273). Using multilevel analysis, ponderal and linear growth were modeled before, during, and after iron supplementation up to 10 y in 3 comparisons: 1) iron supplementation compared with usual nutrition from 6 to 12 mo; 2) iron supplementation compared with usual nutrition from 12 to 18 mo; and 3) 15 mg/d of iron as drops compared with iron-fortified formula (12 mg/L). Growth trajectories did not differ during or after supplementation indicating no adverse effect of iron in any comparison. These results suggest that, at least in some environments, iron does not impair growth in IS infants. |
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Authors:
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Sheila Gahagan; Sunkyung Yu; Niko Kaciroti; Marcela Castillo; Betsy Lozoff |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-09-23 |
Journal Detail:
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Title: The Journal of nutrition Volume: 139 ISSN: 1541-6100 ISO Abbreviation: J. Nutr. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-21 Completed Date: 2010-01-06 Revised Date: 2012-03-13 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 2106-12 Citation Subset: IM |
Affiliation:
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Division of Child Development and Community Health, Department of Pediatrics, Rady Children's Hospital and University of California-San Diego, CA 92093-0831, USA. sgahagan@ucsd.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anemia, Iron-Deficiency
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epidemiology,
prevention & control Body Height Body Weight Chile Dietary Supplements* Female Food Additives / pharmacology* Growth / physiology* Humans Infant Iron / metabolism*, pharmacology* Longitudinal Studies Male Reference Values Retrospective Studies Urban Population World Health World Health Organization |
| Grant Support | |
ID/Acronym/Agency:
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2R01 HD33487-11/HD/NICHD NIH HHS; K23 HD001481/HD/NICHD NIH HHS; R01 HD33487/HD/NICHD NIH HHS; R01 HL088530/HL/NHLBI NIH HHS; R01 HL088530-05/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Food Additives; 7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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