Document Detail

Linear parameter varying system based modeling of hemodynamic response to profiled hemodialysis.
MedLine Citation:
PMID:  21096674     Owner:  NLM     Status:  MEDLINE    
This paper proposes a novel linear parameter varying (LPV) system to model the hemodynamic response of end-stage renal failure patients to profiled hemodialysis (PHD). Ultrafiltration rate (UFR) and dialysate sodium concentration (Na) are imposed as the control inputs and the model computes the relative blood volume (RBV), percentage change in heart rate (ΔDHR(%)) and percentage change in systolic blood pressure (ΔDSBP(%)) during the course of hemodialysis. Model parameters are estimated using least squares approach based on data collected from 12 patients where each patient underwent 4 profile hemodialysis sessions. Parameter identification based on four profiled sessions of the same patient revealed an average mean square error of 0.11 for RBV, 0.24 for ΔDHR and 0.43 for ΔDSBP. The results provided a good model to estimate the individual patient's hemodynamic behavior during hemodialysis. The developed model can play a vital role in designing a robust control system to automatically regulate the UFR and Na while maintaining the hemodynamic variables within stable range.
Faizan Javed; Andrey V Savkin; Gregory S H Chan; James D Mackie; Nigel H Lovell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference     Volume:  2010     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2010  
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-03-29     Revised Date:  2014-08-21    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4967-70     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Blood Pressure*
Blood Volume*
Computer Simulation
Linear Models
Models, Cardiovascular*
Renal Dialysis*
Renal Insufficiency / physiopathology*,  rehabilitation*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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