Document Detail

Linear and non-linear 24 h heart rate variability in chronic heart failure.
MedLine Citation:
PMID:  11269916     Owner:  NLM     Status:  MEDLINE    
It has recently been demonstrated that SDNN of heart rate variability (HRV) is a useful independent prognostic tool in chronic heart failure (CHF). The purpose of the present study was to evaluate if spectral and non-linear analysis of 24-h HRV, considered markers of autonomic cardiac modulation, contain independent prognostic information in CHF patients. Twenty normal subjects and thirty consecutive outpatients with clinically stable CHF were studied for 2 years. Periods of 300 R-R intervals were analyzed from Holter recordings. The power spectral analysis, the slope of the linear relationship between log-power versus log-frequency (1/f), and the complexity content (using corrected conditional entropy; CCE) of the R-R series were calculated. The normalized power of the low frequency spectral component (LF) and the 1/f slope were significantly lower in patients compared to controls (respectively 30.1 +/- 3.0 vs. 48.6 +/- 3.4 and -1.27 +/- 0.04 vs. -1.08 +/- 0.05; P < 0.05). Moreover, the patients who died during the study presented a reduced LF (20.9 +/- 4.1 vs. 35.5 +/- 3.5 nu; P < 0.05) and a steeper 1/f slope (-1.40 +/- 0.09 vs. -1.21 +/- 0.04 nuts, P < 0.05) compared to survivors. These results remained significant in a logistic model including heart rate and SDNN. The information content present in spectral and non-linear analysis of HRV in CHF patients has prognostic relevance independently from the time domain measures of HRV. In particular, the reduction of LF power seems the best indicator among those considered.
S Guzzetti; S Mezzetti; R Magatelli; A Porta; G De Angelis; G Rovelli; A Malliani
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Autonomic neuroscience : basic & clinical     Volume:  86     ISSN:  1566-0702     ISO Abbreviation:  Auton Neurosci     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-03-28     Completed Date:  2001-04-26     Revised Date:  2009-08-12    
Medline Journal Info:
Nlm Unique ID:  100909359     Medline TA:  Auton Neurosci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  114-9     Citation Subset:  IM    
Centro Ricerche Cardiovascolari, CNR, Dipartimento Scienze Precliniche L.I.T.A. Vialba, Medicina Interna II, Ospedale L. Sacco, Universita degli Studi, Via GB Grassi 74, 20157 Milan, Italy.
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MeSH Terms
Arrhythmias, Cardiac / physiopathology*
Chronic Disease
Circadian Rhythm / physiology*
Electrocardiography, Ambulatory
Follow-Up Studies
Heart Failure / physiopathology*
Heart Rate / physiology
Nonlinear Dynamics
Predictive Value of Tests
Survival Analysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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