| Linear longitudinal decline in fractional anisotropy in patients with amyotrophic lateral sclerosis: preliminary results. | |
| | |
MedLine Citation:
|
PMID: 19636503 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND PURPOSE: As potential therapies aimed at halting or slowing the decline in upper motor neuron function in patients with amyotrophic lateral sclerosis (ALS) or primary lateral sclerosis (PLS) are developed, a quantitative method for monitoring response will be necessary. Measurement of fractional anisotropy (FA) using diffusion tensor imaging (DTI) over time should parallel functional decline from upper motor neuron degeneration in these patients. PATIENTS AND METHODS: Two patients with definite ALS were imaged at 3.0 T and FA values were obtained in the corticospinal tract every 3 months for 1 year. The FA values were compared to normal age-matched controls. RESULTS: Both patients showed linear decreases in FA values over time with R(2) values ranging from 0.93 to 0.99. The decline became statistically significant over the course of the study. Qualitative decreases in anisotropy were also evident on FA maps. CONCLUSION: If these trends can be validated in greater numbers of patients, DTI may serve as an objective quantitative biomarker for disease progression in patients with upper motor neuron disease. |
| | |
Authors:
|
Joshua P Nickerson; Christopher J Koski; Andrew C Boyer; Heather N Burbank; Rup Tandan; Christopher G Filippi |
Related Documents
:
|
17415083 - The neuropsychiatry of multiple sclerosis: a review of recent developments. 14568133 - Autonomic nervous system function in multiple sclerosis. 11128823 - A follow-up study of 60 patients after an assumed first period of cluster headache. |
Publication Detail:
|
Type: Journal Article Date: 2009-05-23 |
Journal Detail:
|
Title: Klinische Neuroradiologie Volume: 19 ISSN: 1615-6706 ISO Abbreviation: Klin Neuroradiol Publication Date: 2009 Jun |
Date Detail:
|
Created Date: 2009-07-28 Completed Date: 2009-10-23 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9422582 Medline TA: Klin Neuroradiol Country: Germany |
Other Details:
|
Languages: eng Pagination: 129-34 Citation Subset: IM |
Affiliation:
|
Department of Radiology, Fletcher Allen Healthcare/The University of Vermont, 111 Colchester Ave., Burlington, VT 05401, USA. Joshua.Nickerson@vtmednet.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Amyotrophic Lateral Sclerosis / pathology*, radiography* Anisotropy Diffusion Magnetic Resonance Imaging / methods Disease Progression Fasciculation / etiology Female Humans Male Middle Aged Motor Neuron Disease / pathology, radiography Pyramidal Tracts / physiopathology, radiography Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Transarterial embolization of intracranial dural arteriovenous fistulas with direct cortical venous ...
Next Document: Activation of primary and secondary somatosensory regions following tactile stimulation of the face.