Document Detail


Linear insertion of atrioventricular valves without septal defect: a new anatomical landmark for Down's syndrome?
MedLine Citation:
PMID:  11914575     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Our objective was to explore whether minor anatomical abnormalities of the septal insertion of tricuspid and mitral valves could be a feature of trisomy 21 in fetuses with an otherwise normal heart. Postmortem examinations were performed in 41 fetuses affected by Down's syndrome and in 52 controls. Adjoining the standard postmortem procedure, an apex-to-base section of the crux of the heart was made on a plane corresponding to the sonographic four-chamber view. This allowed gross and histological examination of the hinge points of tricuspid and mitral leaflets, showing the usual apical displacement of the tricuspid valve in all controls. Of 41 fetuses affected by Down's syndrome, 18 had a structural heart defect. Of the 23 Down syndrome fetuses without a patent heart defect, 16 (i.e., 69% of those considered as having 'normal hearts') had nevertheless a linear insertion of atrioventricular valves at autopsy. Prospective clinical studies are required to evaluate if these postmortem findings can be transposed to the clinical setting of 2nd-trimester sonographic screening.
Authors:
C Fredouille; M-D Piercecchi-Marti; A Liprandi; M Duyme; M Gonzales; N Bigi; F Rouault; J F Pellissier
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  17     ISSN:  1015-3837     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:    2002 May-Jun
Date Detail:
Created Date:  2002-03-26     Completed Date:  2002-09-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  188-92     Citation Subset:  IM    
Copyright Information:
Copyright 2002 S. Karger AG, Basel
Affiliation:
Service Pr M. Gamerre, Unité de Foeto-Placentologie, Service d'Anatomopathologie et de Neuropathologie, Hôpital de la Timone, Marseille, France. ccousin@mail.ap-hm.fr
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MeSH Terms
Descriptor/Qualifier:
Down Syndrome / complications*
Female
Heart Atria
Heart Septal Defects, Atrial / complications*
Heart Septal Defects, Ventricular / complications*
Heart Ventricles
Humans
Mitral Valve / abnormalities
Pregnancy
Prospective Studies
Tricuspid Valve / abnormalities*
Ultrasonography, Prenatal
Comments/Corrections
Erratum In:
Fetal Diagn Ther. 2002 Sep-Oct;;17(5):292

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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