| Linear dose response and quantitative attenuation by potassium of the inotropic action of acetylstrophanthidin. | |
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MedLine Citation:
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PMID: 872494 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To evaluate the nature of the inotropic dose response of digitalis and to determine the effects of potassium on this response, isometrically contracting isolated supported right ventricular cat papillary muscles were studied relative to their peak tension and peak dT/dt increases to physiologic cumulative doses of acetylstrophanthidin (ACS) in different extracellular potassium concentrations in the muscle bath. The inotropic dose response to ACS was observed to be linear in cumulative glycoside concentrations ranging from 0.40 to 4.23 X 10(-7) M ACS in 3.5 mM K+ medium and from 1.22 to 7.47 X 10(-7) M ACS in 7.0 mM K+ medium. The influence of potassium alterations in the muscle bath from the low to the high K+ concentrations prior to ACS resulted in marked attenuation of the positive inotropic property of ACS. From these data, it is concluded that the dose inotropic response of digitalis is linear, with small doses producing proportionally the same effects as larger doses, and that extracellular potassium markedly influences this linear dose response such that higher K+ concentrations considerably attenuate the positive inotropic response of digitalis. |
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Authors:
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G Lee; R Zelis; D T Mason |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Clinical pharmacology and therapeutics Volume: 22 ISSN: 0009-9236 ISO Abbreviation: Clin. Pharmacol. Ther. Publication Date: 1977 Jul |
Date Detail:
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Created Date: 1977-08-25 Completed Date: 1977-08-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372741 Medline TA: Clin Pharmacol Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 34-41 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cats Dose-Response Relationship, Drug Electric Stimulation Myocardial Contraction / drug effects* Osmolar Concentration Potassium / pharmacology* Strophanthidin / analogs & derivatives*, antagonists & inhibitors, pharmacology |
| Chemical | |
Reg. No./Substance:
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66-28-4/Strophanthidin; 7440-09-7/Potassium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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