Document Detail


Lineage-dependent circuit assembly in the neocortex.
MedLine Citation:
PMID:  23757410     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The neocortex plays a key role in higher-order brain functions, such as perception, language and decision-making. Since the groundbreaking work of Ramón y Cajal over a century ago, defining the neural circuits underlying brain functions has been a field of intense study. Here, we review recent findings on the formation of neocortical circuits, which have taken advantage of improvements to mouse genetics and circuit-mapping tools. These findings are beginning to reveal how individual components of circuits are generated and assembled during development, and how early developmental processes, such as neurogenesis and neuronal migration, guide precise circuit assembly.
Authors:
Peng Gao; Khadeejah T Sultan; Xin-Jun Zhang; Song-Hai Shi
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  140     ISSN:  1477-9129     ISO Abbreviation:  Development     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-12     Completed Date:  2013-08-20     Revised Date:  2014-07-01    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  2645-55     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Movement / genetics,  physiology
Humans
Neocortex / cytology*,  metabolism
Neurogenesis / genetics,  physiology
Neurons / cytology,  metabolism
Grant Support
ID/Acronym/Agency:
P01 NS048120/NS/NINDS NIH HHS; P30 CA008748/CA/NCI NIH HHS
Comments/Corrections

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